Invited review

Mechanisms underlying motor unit plasticity in the respiratory system

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Neuromotor control of skeletal muscles, including respiratory muscles, is ultimately dependent on the function of the motor unit (comprising an individual motoneuron and the muscle fibers it innervates). Considerable diversity exists across diaphragm motor units, yet remarkable homogeneity is present (and maintained) within motor units. In recent years, the mechanisms underlying the development and adaptability of respiratory motor units have received great attention, leading to significant advances in our understanding of diaphragm motor unit plasticity. For example, following imposed inactivity of the diaphragm muscle, there are changes at phrenic motoneurons, neuromuscular junctions, and muscle fibers that tend to restore the ability of the diaphragm to sustain ventilation. The role of activity, neurotrophins, and other growth factors in modulating this adaptability is discussed.

Original languageEnglish (US)
Pages (from-to)1230-1241
Number of pages12
JournalJournal of Applied Physiology
Volume94
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Diaphragm
Respiratory System
Motor Neurons
Muscles
Respiratory Muscles
Neuromuscular Junction
Nerve Growth Factors
Ventilation
Intercellular Signaling Peptides and Proteins
Skeletal Muscle

Keywords

  • Diaphragm muscle
  • Inactivity
  • Neurotrophins
  • Phrenic nerve
  • Respiration

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Invited review : Mechanisms underlying motor unit plasticity in the respiratory system. / Mantilla, Carlos Bernardo; Sieck, Gary C.

In: Journal of Applied Physiology, Vol. 94, No. 3, 01.03.2003, p. 1230-1241.

Research output: Contribution to journalArticle

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