Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Shear wave elastography with acoustic radiation force (ARF) or harmonic vibration (HV) has been applied in animals and humans to evaluate myocardial material properties. The anisotropic myocardial structure presents a unique challenge to wave propagation methods because the fiber direction changes through the wall thickness. To investigate the effects of the frequency of excitation in the myocardium we constructed systolic and diastolic finite element models (FEMs) and performed an experiment on an ex vivo porcine heart. Both models were constructed with multiple elastic, transverse isotropic layers with a shear wave velocity (SWV) along and across the fibers where each layer has 1 mm thickness with the top and bottom in contact with water. The orientation of the muscle fibers was changed for each layer ranging from -50° to 80° from top to bottom. Harmonic excitations at 30, 50, 100, and 200 Hz and an impulsive force were used. An ex vivo porcine heart was tested using ARF excitations with a transesophogeal probe driven with a Verasonics ultrasound system applied directly to the left ventricular wall. We evaluated the measured orientation of the fibers in each layer by evaluating the angle with the highest SWV. The 30 and 50 Hz results showed little or no variation in the measured orientation angle in the layers. The 100 and 200 Hz results showed some variation of the orientation with respect to the layer. The impulse simulation results showed good agreement with the true orientations except near the top and bottom boundaries. The values of SWV were found to have different levels of bias depending on the excitation. The experimental results in the ex vivo heart showed similar trends as the FEM model results where the waves at lower frequencies had lower sensitivity to fiber direction. This multi-layered anisotropic model demonstrates how to resolve different anisotropic layers in the myocardium using ARF or HV while also revealing that using lower frequencies results in measurements that are less sensitive to anisotropy variation through the thickness of the myocardial wall.

Original languageEnglish (US)
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479981823
DOIs
StatePublished - Nov 13 2015
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
Duration: Oct 21 2015Oct 24 2015

Other

OtherIEEE International Ultrasonics Symposium, IUS 2015
CountryTaiwan, Province of China
CityTaipei
Period10/21/1510/24/15

Fingerprint

sound waves
S waves
harmonics
vibration
anisotropy
myocardium
fibers
muscle fibers
low frequencies
excitation
harmonic excitation
animals
impulses
wave propagation
trends
probes
sensitivity
water
simulation

Keywords

  • acoustic radiation force
  • anisotropy
  • frequency
  • heart
  • shear wave
  • transverse isotropy
  • vibration

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Urban, M. W., Qiang, B., Song, P., Nenadic, I. Z., Chen, S. D., & Greenleaf, J. F. (2015). Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329584] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2015.0154

Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration. / Urban, Matthew W; Qiang, Bo; Song, Pengfei; Nenadic, Ivan Z.; Chen, Shigao D; Greenleaf, James F.

2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7329584.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Urban, MW, Qiang, B, Song, P, Nenadic, IZ, Chen, SD & Greenleaf, JF 2015, Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration. in 2015 IEEE International Ultrasonics Symposium, IUS 2015., 7329584, Institute of Electrical and Electronics Engineers Inc., IEEE International Ultrasonics Symposium, IUS 2015, Taipei, Taiwan, Province of China, 10/21/15. https://doi.org/10.1109/ULTSYM.2015.0154
Urban MW, Qiang B, Song P, Nenadic IZ, Chen SD, Greenleaf JF. Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration. In 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7329584 https://doi.org/10.1109/ULTSYM.2015.0154
Urban, Matthew W ; Qiang, Bo ; Song, Pengfei ; Nenadic, Ivan Z. ; Chen, Shigao D ; Greenleaf, James F. / Investigation of the effects of myocardial anisotropy for shear wave elastography using acoustic radiation force and harmonic vibration. 2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015.
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abstract = "Shear wave elastography with acoustic radiation force (ARF) or harmonic vibration (HV) has been applied in animals and humans to evaluate myocardial material properties. The anisotropic myocardial structure presents a unique challenge to wave propagation methods because the fiber direction changes through the wall thickness. To investigate the effects of the frequency of excitation in the myocardium we constructed systolic and diastolic finite element models (FEMs) and performed an experiment on an ex vivo porcine heart. Both models were constructed with multiple elastic, transverse isotropic layers with a shear wave velocity (SWV) along and across the fibers where each layer has 1 mm thickness with the top and bottom in contact with water. The orientation of the muscle fibers was changed for each layer ranging from -50° to 80° from top to bottom. Harmonic excitations at 30, 50, 100, and 200 Hz and an impulsive force were used. An ex vivo porcine heart was tested using ARF excitations with a transesophogeal probe driven with a Verasonics ultrasound system applied directly to the left ventricular wall. We evaluated the measured orientation of the fibers in each layer by evaluating the angle with the highest SWV. The 30 and 50 Hz results showed little or no variation in the measured orientation angle in the layers. The 100 and 200 Hz results showed some variation of the orientation with respect to the layer. The impulse simulation results showed good agreement with the true orientations except near the top and bottom boundaries. The values of SWV were found to have different levels of bias depending on the excitation. The experimental results in the ex vivo heart showed similar trends as the FEM model results where the waves at lower frequencies had lower sensitivity to fiber direction. This multi-layered anisotropic model demonstrates how to resolve different anisotropic layers in the myocardium using ARF or HV while also revealing that using lower frequencies results in measurements that are less sensitive to anisotropy variation through the thickness of the myocardial wall.",
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AB - Shear wave elastography with acoustic radiation force (ARF) or harmonic vibration (HV) has been applied in animals and humans to evaluate myocardial material properties. The anisotropic myocardial structure presents a unique challenge to wave propagation methods because the fiber direction changes through the wall thickness. To investigate the effects of the frequency of excitation in the myocardium we constructed systolic and diastolic finite element models (FEMs) and performed an experiment on an ex vivo porcine heart. Both models were constructed with multiple elastic, transverse isotropic layers with a shear wave velocity (SWV) along and across the fibers where each layer has 1 mm thickness with the top and bottom in contact with water. The orientation of the muscle fibers was changed for each layer ranging from -50° to 80° from top to bottom. Harmonic excitations at 30, 50, 100, and 200 Hz and an impulsive force were used. An ex vivo porcine heart was tested using ARF excitations with a transesophogeal probe driven with a Verasonics ultrasound system applied directly to the left ventricular wall. We evaluated the measured orientation of the fibers in each layer by evaluating the angle with the highest SWV. The 30 and 50 Hz results showed little or no variation in the measured orientation angle in the layers. The 100 and 200 Hz results showed some variation of the orientation with respect to the layer. The impulse simulation results showed good agreement with the true orientations except near the top and bottom boundaries. The values of SWV were found to have different levels of bias depending on the excitation. The experimental results in the ex vivo heart showed similar trends as the FEM model results where the waves at lower frequencies had lower sensitivity to fiber direction. This multi-layered anisotropic model demonstrates how to resolve different anisotropic layers in the myocardium using ARF or HV while also revealing that using lower frequencies results in measurements that are less sensitive to anisotropy variation through the thickness of the myocardial wall.

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