Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice

Abba Zubair, S. A. Ali, R. C. Rees, J. R. Goepel, M. H. Goyns

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have assessed the effectiveness of the metalloproteinase inhibitor BB-94 (batimastat) in reducing the colonization potential of the human Burkitt lymphoma Namalwa cell line. In this study Namalwa cells were injected intraperitoneally into SCID mice and their spread to the spleen, liver and lung studied over a 3 week period. The human cells were detected in the mouse tissues by polymerase chain reaction (PCR) amplification of a human alu repeat sequence. Comparison of BB-94-treated animals with an untreated control group provided no evidence for a significant reduction in the colonization of mouse tissues by the human lymphoma cells in the presence of the drug. Tumour growth, after subcutaneous injection of the Namalwa cells into SCID mice, was similarly unaffected by BB-94. The significance of these results is discussed.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalCancer Letters
Volume107
Issue number1
DOIs
StatePublished - Oct 1 1996
Externally publishedYes

Fingerprint

SCID Mice
Lymphoma
Burkitt Lymphoma
Metalloproteases
Subcutaneous Injections
Spleen
Cell Line
Polymerase Chain Reaction
Lung
Control Groups
batimastat
Liver
Growth
Pharmaceutical Preparations
Neoplasms

Keywords

  • BB-94
  • Namalwa
  • Non-Hogkin's lymphoma
  • SCID mice

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice. / Zubair, Abba; Ali, S. A.; Rees, R. C.; Goepel, J. R.; Goyns, M. H.

In: Cancer Letters, Vol. 107, No. 1, 01.10.1996, p. 91-95.

Research output: Contribution to journalArticle

Zubair, Abba ; Ali, S. A. ; Rees, R. C. ; Goepel, J. R. ; Goyns, M. H. / Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice. In: Cancer Letters. 1996 ; Vol. 107, No. 1. pp. 91-95.
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