Investigation of statistical decision rules for sequential hematologic laboratory tests

G. G. Klee, E. Ackerman, L. R. Elveback, L. C. Gatewood, R. V. Pierre, M. B. O'Sullivan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A statistical data processing program for identifying patients who are likely to have abnormalities on various hematologic laboratory tests is described. The prediction of abnormal levels of serum vitamin B 12, serum folate, transferrin saturation, and reticulocyte counts is based on a statistical analysis of the patient's age, sex, and routine blood cell measurements. The program was developed using data from normal-value studies and data from patients who had these laboratory abnormalities. The sensitivity and specificity of the program were evaluated in a controlled prospective study of about 5,000 ambulatory adult patients. The program's predictions also were compared with the laboratory tests requested by the patients' attending physicians. The program was most sensitive for predicting low serum vitamin B 12 (74%) and low transferrin saturation (78%). In the prospective evaluation, the predictive values varied from 11% for predicting low serum folate to 65% for predicting low transferrin saturation.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume69
Issue number4
StatePublished - 1978

Fingerprint

Hematologic Tests
Transferrin
Vitamin B 12
Serum
Folic Acid
Reticulocyte Count
Blood Cells
Reference Values
Prospective Studies
Physicians
Sensitivity and Specificity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Klee, G. G., Ackerman, E., Elveback, L. R., Gatewood, L. C., Pierre, R. V., & O'Sullivan, M. B. (1978). Investigation of statistical decision rules for sequential hematologic laboratory tests. American Journal of Clinical Pathology, 69(4), 375-382.

Investigation of statistical decision rules for sequential hematologic laboratory tests. / Klee, G. G.; Ackerman, E.; Elveback, L. R.; Gatewood, L. C.; Pierre, R. V.; O'Sullivan, M. B.

In: American Journal of Clinical Pathology, Vol. 69, No. 4, 1978, p. 375-382.

Research output: Contribution to journalArticle

Klee, GG, Ackerman, E, Elveback, LR, Gatewood, LC, Pierre, RV & O'Sullivan, MB 1978, 'Investigation of statistical decision rules for sequential hematologic laboratory tests', American Journal of Clinical Pathology, vol. 69, no. 4, pp. 375-382.
Klee GG, Ackerman E, Elveback LR, Gatewood LC, Pierre RV, O'Sullivan MB. Investigation of statistical decision rules for sequential hematologic laboratory tests. American Journal of Clinical Pathology. 1978;69(4):375-382.
Klee, G. G. ; Ackerman, E. ; Elveback, L. R. ; Gatewood, L. C. ; Pierre, R. V. ; O'Sullivan, M. B. / Investigation of statistical decision rules for sequential hematologic laboratory tests. In: American Journal of Clinical Pathology. 1978 ; Vol. 69, No. 4. pp. 375-382.
@article{80919abbace24034819eae7c158211a8,
title = "Investigation of statistical decision rules for sequential hematologic laboratory tests",
abstract = "A statistical data processing program for identifying patients who are likely to have abnormalities on various hematologic laboratory tests is described. The prediction of abnormal levels of serum vitamin B 12, serum folate, transferrin saturation, and reticulocyte counts is based on a statistical analysis of the patient's age, sex, and routine blood cell measurements. The program was developed using data from normal-value studies and data from patients who had these laboratory abnormalities. The sensitivity and specificity of the program were evaluated in a controlled prospective study of about 5,000 ambulatory adult patients. The program's predictions also were compared with the laboratory tests requested by the patients' attending physicians. The program was most sensitive for predicting low serum vitamin B 12 (74{\%}) and low transferrin saturation (78{\%}). In the prospective evaluation, the predictive values varied from 11{\%} for predicting low serum folate to 65{\%} for predicting low transferrin saturation.",
author = "Klee, {G. G.} and E. Ackerman and Elveback, {L. R.} and Gatewood, {L. C.} and Pierre, {R. V.} and O'Sullivan, {M. B.}",
year = "1978",
language = "English (US)",
volume = "69",
pages = "375--382",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "4",

}

TY - JOUR

T1 - Investigation of statistical decision rules for sequential hematologic laboratory tests

AU - Klee, G. G.

AU - Ackerman, E.

AU - Elveback, L. R.

AU - Gatewood, L. C.

AU - Pierre, R. V.

AU - O'Sullivan, M. B.

PY - 1978

Y1 - 1978

N2 - A statistical data processing program for identifying patients who are likely to have abnormalities on various hematologic laboratory tests is described. The prediction of abnormal levels of serum vitamin B 12, serum folate, transferrin saturation, and reticulocyte counts is based on a statistical analysis of the patient's age, sex, and routine blood cell measurements. The program was developed using data from normal-value studies and data from patients who had these laboratory abnormalities. The sensitivity and specificity of the program were evaluated in a controlled prospective study of about 5,000 ambulatory adult patients. The program's predictions also were compared with the laboratory tests requested by the patients' attending physicians. The program was most sensitive for predicting low serum vitamin B 12 (74%) and low transferrin saturation (78%). In the prospective evaluation, the predictive values varied from 11% for predicting low serum folate to 65% for predicting low transferrin saturation.

AB - A statistical data processing program for identifying patients who are likely to have abnormalities on various hematologic laboratory tests is described. The prediction of abnormal levels of serum vitamin B 12, serum folate, transferrin saturation, and reticulocyte counts is based on a statistical analysis of the patient's age, sex, and routine blood cell measurements. The program was developed using data from normal-value studies and data from patients who had these laboratory abnormalities. The sensitivity and specificity of the program were evaluated in a controlled prospective study of about 5,000 ambulatory adult patients. The program's predictions also were compared with the laboratory tests requested by the patients' attending physicians. The program was most sensitive for predicting low serum vitamin B 12 (74%) and low transferrin saturation (78%). In the prospective evaluation, the predictive values varied from 11% for predicting low serum folate to 65% for predicting low transferrin saturation.

UR - http://www.scopus.com/inward/record.url?scp=0018131216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018131216&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 375

EP - 382

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 4

ER -