Investigating the Effect of Tau Deposition and Apoe on Hippocampal Morphometry in Alzheimer's Disease: A Federated Chow Test Model

Jianfeng Wu, Yi Su, Eric M. Reiman, Richard J. Caselli, Kewei Chen, Paul M. Thompson, Junwen Wang, Yalin Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease (AD) affects more than 1 in 9 people age 65 and older and becomes an urgent public health concern as the global population ages. Tau tangle is the specific protein pathological hallmark of AD and plays a crucial role in leading to dementia-related structural deformations observed in magnetic resonance imaging (MRI) scans. The volume loss of hippocampus is mainly related to the development of AD. Besides, apolipoprotein E (APOE) also has significant effects on the risk of developing AD. However, few studies focus on integrating genotypes, MRI, and tau deposition to infer multimodal relationships. In this paper, we proposed a federated chow test model to study the synergistic effects of APOE and tau on hippocampal morphometry. Our experimental results demonstrate our model can detect the difference of tau deposition and hippocampal atrophy among the cohorts with different genotypes and subiculum and cornu ammonis 1 (CA1 subfield) were identified as hippocampal subregions where atrophy is strongly associated with abnormal tau in the homozygote cohort. Our model will provide novel insight into the neural mechanisms about the individual impact of APOE and tau deposition on brain imaging.

Original languageEnglish (US)
Title of host publicationISBI 2022 - Proceedings
Subtitle of host publication2022 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
ISBN (Electronic)9781665429238
DOIs
StatePublished - 2022
Event19th IEEE International Symposium on Biomedical Imaging, ISBI 2022 - Kolkata, India
Duration: Mar 28 2022Mar 31 2022

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2022-March
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference19th IEEE International Symposium on Biomedical Imaging, ISBI 2022
Country/TerritoryIndia
CityKolkata
Period3/28/223/31/22

Keywords

  • Alzheimer's Disease
  • APOE
  • federated chow test
  • Hippocampal Morphometry
  • tau deposition

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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