TY - JOUR
T1 - Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases
AU - Ung, Choong Yong
AU - Lam, Siew Hong
AU - Zhang, Xun
AU - Li, Hu
AU - Zhang, Louxin
AU - Li, Baowen
AU - Gong, Zhiyuan
PY - 2013/2/14
Y1 - 2013/2/14
N2 - The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders.
AB - The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders.
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U2 - 10.1371/journal.pone.0056668
DO - 10.1371/journal.pone.0056668
M3 - Article
C2 - 23457601
AN - SCOPUS:84874010307
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 2
M1 - e56668
ER -