Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases

Choong Yong Ung, Siew Hong Lam, Xun Zhang, Hu Li, Louxin Zhang, Baowen Li, Zhiyuan Gong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders.

Original languageEnglish (US)
Article numbere56668
JournalPLoS One
Volume8
Issue number2
DOIs
StatePublished - Feb 14 2013
Externally publishedYes

Fingerprint

toxic substances
Genes
gender
genes
toxicogenomics
Toxicogenetics
Sex Factors
Zebrafish
transcriptomics
Danio rerio
Up-Regulation
Down-Regulation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases. / Ung, Choong Yong; Lam, Siew Hong; Zhang, Xun; Li, Hu; Zhang, Louxin; Li, Baowen; Gong, Zhiyuan.

In: PLoS One, Vol. 8, No. 2, e56668, 14.02.2013.

Research output: Contribution to journalArticle

Ung, Choong Yong ; Lam, Siew Hong ; Zhang, Xun ; Li, Hu ; Zhang, Louxin ; Li, Baowen ; Gong, Zhiyuan. / Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases. In: PLoS One. 2013 ; Vol. 8, No. 2.
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