Inverse method for estimating elastic modulus of arterial walls

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Pulse wave velocity (PWV) is widely used for estimating the stiffness of an artery. It is well known that a stiffened artery can be associated with various diseases and with aging and disease. Usually, PWV is measured using the "foot-to-foot" method. The "foot" of the pressure wave is not clear due to reflected waves and blood noise. Also, PWV is an average indicator of artery stiffness between the two measuring points, and therefore does not identify local stiffness variations. We propose producing a flexural wave in the arterial wall using low frequency localized ultrasound radiation force and measuring the wave velocity along the arterial wall. The wave velocity can be measured accurately over a few millimeters. A mathematical model for wave propagation along the artery is developed with which the Young's modulus of the artery can be determined from measured wave velocities. Experiments were conducted on a pig carotid artery in gelatin. The wave velocity was measured by the phase change at a known distance for a given frequency. The measured wave velocity is about 3 m/s at 100 Hz and 6.5 m/s at 500 Hz. The real part of complex elastic modulus of the artery is estimated to be 300 kPa.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.J. Yaffe, M.J. Flynn
Pages226-235
Number of pages10
Volume5368
Edition1
DOIs
StatePublished - 2004
EventMedical Imaging 2004: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 15 2004Feb 17 2004

Other

OtherMedical Imaging 2004: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/15/042/17/04

Fingerprint

modulus of elasticity
arteries
estimating
Elastic moduli
stiffness
Stiffness
pulses
swine
gelatins
reflected waves
Elastic waves
elastic waves
blood
wave propagation
mathematical models
Wave propagation
Blood
Aging of materials
Ultrasonics
low frequencies

Keywords

  • Artery
  • Elastic modulus
  • Pulse wave velocity
  • Radial dilation
  • Ultrasound
  • Viscoelasticity

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Zhang, X., Fatemi, M., & Greenleaf, J. F. (2004). Inverse method for estimating elastic modulus of arterial walls. In M. J. Yaffe, & M. J. Flynn (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (1 ed., Vol. 5368, pp. 226-235) https://doi.org/10.1117/12.532760

Inverse method for estimating elastic modulus of arterial walls. / Zhang, Xiaoming; Fatemi, Mostafa; Greenleaf, James F.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M.J. Yaffe; M.J. Flynn. Vol. 5368 1. ed. 2004. p. 226-235.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, X, Fatemi, M & Greenleaf, JF 2004, Inverse method for estimating elastic modulus of arterial walls. in MJ Yaffe & MJ Flynn (eds), Proceedings of SPIE - The International Society for Optical Engineering. 1 edn, vol. 5368, pp. 226-235, Medical Imaging 2004: Physics of Medical Imaging, San Diego, CA, United States, 2/15/04. https://doi.org/10.1117/12.532760
Zhang X, Fatemi M, Greenleaf JF. Inverse method for estimating elastic modulus of arterial walls. In Yaffe MJ, Flynn MJ, editors, Proceedings of SPIE - The International Society for Optical Engineering. 1 ed. Vol. 5368. 2004. p. 226-235 https://doi.org/10.1117/12.532760
Zhang, Xiaoming ; Fatemi, Mostafa ; Greenleaf, James F. / Inverse method for estimating elastic modulus of arterial walls. Proceedings of SPIE - The International Society for Optical Engineering. editor / M.J. Yaffe ; M.J. Flynn. Vol. 5368 1. ed. 2004. pp. 226-235
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