Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies

Irena Balzekas, Vladimir Sladky, Petr Nejedly, Benjamin H. Brinkmann, Daniel Crepeau, Filip Mivalt, Nicholas M. Gregg, Tal Pal Attia, Victoria S. Marks, Lydia Wheeler, Tori E. Riccelli, Jeffrey P. Staab, Brian Nils Lundstrom, Kai J. Miller, Jamie Van Gompel, Vaclav Kremen, Paul E. Croarkin, Gregory A. Worrell

Research output: Contribution to journalArticlepeer-review

Abstract

Intracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug-resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental in studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.

Original languageEnglish (US)
Article number702605
JournalFrontiers in Human Neuroscience
Volume15
DOIs
StatePublished - Jul 26 2021

Keywords

  • biomarker
  • deep brain stimulation
  • electrocorticography (ECoG)
  • epilepsy
  • major depression (MDD)
  • neuromodulation
  • psychiatric disorders
  • SEEG (stereoelectroencephalography)

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

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