Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either the clinical syndromes or the anatomical distribution of pathology. In contrast, this book takes a different approach by using a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells or in the extracellular compartments or according to a shared pathogenetic mechanism, such as trinucleotide repeats that are a feature of specific genetic disorders.

Original languageEnglish (US)
Title of host publicationNeurodegeneration
Subtitle of host publicationThe Molecular Pathology of Dementia and Movement Disorders: Second Edition
PublisherWiley-Blackwell
Pages1-5
Number of pages5
ISBN (Print)9781405196932
DOIs
StatePublished - Sep 21 2011

Keywords

  • Alzheimer's disease (AD)
  • Creutzfeld-Jakob disease (CJD)
  • Familial british dementia (FBD)
  • Huntington's disease (HD)
  • Microglia
  • Neurodegenerative diseases and neuronal loss
  • Post-translational modification of proteins
  • Shared mechanisms

ASJC Scopus subject areas

  • Medicine(all)

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    Dickson, D. W. (2011). Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. In Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition (pp. 1-5). Wiley-Blackwell. https://doi.org/10.1002/9781444341256.ch1