Introduction

Michael J. Thun, Martha S. Linet, James R Cerhan, Christopher Haiman, David Schottenfeld

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This Introduction provides a broad overview of the scientific advances and crosscutting developments that increasingly influence epidemiologic research on the causes and prevention of cancer. High-throughput technologies have identified the molecular “driver” events in tumor tissue that underlie the multistage development of many types of cancer. These somatic (largely acquired) alterations disrupt normal genetic and epigenetic control over cell maintenance, division and survival. Tumor classification is also changing to reflect the genetic and molecular alterations in tumor tissue, as well as the anatomic, morphologic, and histologic phenotype of the cancer. Genome-wide association studies (GWAS) have identified more than 700 germline (inherited) genetic loci associated with susceptibility to various forms of cancer, although the risk estimates for almost all of these are small to modest and their exact location and function remain to identified. Advances in genomic and other “OMIC” technologies are identifying biomarkers that reflect internal exposures, biological processes and intermediate outcomes in large population studies. While research in many of these areas is still in its infancy, mechanistic and molecular assays are increasingly incorporated into etiologic studies and inferences about causation. Other sections of the book discuss the global public health impact of cancer, the growing list of exposures known to affect cancer risk, the epidemiology of over 30 types of cancer by tissue of origin, and preventive interventions that have dramatically reduced the incidence rates of several major cancers.

Original languageEnglish (US)
Title of host publicationSchottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition
PublisherOxford University Press
Pages1-6
Number of pages6
ISBN (Electronic)9780190238667
DOIs
StatePublished - Jan 1 2017

Fingerprint

Neoplasms
Technology
Biological Phenomena
Genetic Loci
Genome-Wide Association Study
Research
Epigenomics
Causality
Cell Division
Molecular Biology
Cell Survival
Epidemiology
Public Health
Biomarkers
Maintenance
Phenotype
Incidence
Population

Keywords

  • Cancer
  • Epidemiology
  • Epigenetic
  • Genetic
  • Neoplasia
  • Tumor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thun, M. J., Linet, M. S., Cerhan, J. R., Haiman, C., & Schottenfeld, D. (2017). Introduction. In Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition (pp. 1-6). Oxford University Press. https://doi.org/10.1093/oso/9780190238667.003.0001

Introduction. / Thun, Michael J.; Linet, Martha S.; Cerhan, James R; Haiman, Christopher; Schottenfeld, David.

Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, 2017. p. 1-6.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thun, MJ, Linet, MS, Cerhan, JR, Haiman, C & Schottenfeld, D 2017, Introduction. in Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, pp. 1-6. https://doi.org/10.1093/oso/9780190238667.003.0001
Thun MJ, Linet MS, Cerhan JR, Haiman C, Schottenfeld D. Introduction. In Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press. 2017. p. 1-6 https://doi.org/10.1093/oso/9780190238667.003.0001
Thun, Michael J. ; Linet, Martha S. ; Cerhan, James R ; Haiman, Christopher ; Schottenfeld, David. / Introduction. Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, 2017. pp. 1-6
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