Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes

John O. Mason, Mamta D. Somaiya, Ravinder J. Singh

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Purpose: To determine the intravitreal concentration and clearance of triamcinolone acetonide at various intervals after intravitreal injection into nonvitrectomized eyes. Methods: Six participants were administered 4 mg (0.1 cc) of triamcinolone acetonide ophthalmic suspension. All six eyes underwent therapeutic pars plana vitrectomy with membranectomy at various post injection intervals ranging from 1.25 to 5 months from the intravitreal injection. Undiluted specimens of vitreous overlying the macula and of aqueous humor were submitted for analysis. Vitreous and aqueous humor concentrations of triamcinolone were measured by high performance liquid chromatography. Results: Four eyes demonstrated detectable intravitreal concentrations of triamcinolone acetonide between 1.25 and 2.75 months after a single injection. Two eyes had an undetectable level of triamcinolone in both the vitreous and aqueous at 3 and 5 months post single injection. Conclusions: The intravitreal concentration of triamcinolone acetonide is detectable up to 2.75 months post a single 4 mg injection in nonvitrectomized eyes. A reinjection interval of 3 months may be needed to achieve sustained measurable levels of triamcinolone in nonvitrectomized patients.

Original languageEnglish (US)
Pages (from-to)900-904
Number of pages5
JournalRetina
Volume24
Issue number6
DOIs
StatePublished - Dec 2004

Keywords

  • Intravitreal concentration
  • Pharmacokinetics
  • Triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes'. Together they form a unique fingerprint.

Cite this