Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes

John O. Mason, Mamta D. Somaiya, Ravinder Jit Singh

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Purpose: To determine the intravitreal concentration and clearance of triamcinolone acetonide at various intervals after intravitreal injection into nonvitrectomized eyes. Methods: Six participants were administered 4 mg (0.1 cc) of triamcinolone acetonide ophthalmic suspension. All six eyes underwent therapeutic pars plana vitrectomy with membranectomy at various post injection intervals ranging from 1.25 to 5 months from the intravitreal injection. Undiluted specimens of vitreous overlying the macula and of aqueous humor were submitted for analysis. Vitreous and aqueous humor concentrations of triamcinolone were measured by high performance liquid chromatography. Results: Four eyes demonstrated detectable intravitreal concentrations of triamcinolone acetonide between 1.25 and 2.75 months after a single injection. Two eyes had an undetectable level of triamcinolone in both the vitreous and aqueous at 3 and 5 months post single injection. Conclusions: The intravitreal concentration of triamcinolone acetonide is detectable up to 2.75 months post a single 4 mg injection in nonvitrectomized eyes. A reinjection interval of 3 months may be needed to achieve sustained measurable levels of triamcinolone in nonvitrectomized patients.

Original languageEnglish (US)
Pages (from-to)900-904
Number of pages5
JournalRetina
Volume24
Issue number6
DOIs
StatePublished - Dec 2004

Fingerprint

Triamcinolone Acetonide
Triamcinolone
Intravitreal Injections
Injections
Aqueous Humor
Vitreous Body
Temazepam
Vitrectomy
Suspensions
High Pressure Liquid Chromatography

Keywords

  • Intravitreal concentration
  • Pharmacokinetics
  • Triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes. / Mason, John O.; Somaiya, Mamta D.; Singh, Ravinder Jit.

In: Retina, Vol. 24, No. 6, 12.2004, p. 900-904.

Research output: Contribution to journalArticle

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