Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy

Catherine S. Morris; Melanie C. Bois; Charles H. Aust; Ryan Thomas; Sanjeev Sethi; Joseph J. Maleszewski

doi:10.1016/j.carpath.2019.04.006

Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy

Catherine S. Morris, Melanie C. Bois, Charles H. Aust, Ryan Thomas, Sanjeev Sethi, Joseph J. Maleszewski

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any other organ. Herein we present the first recognized case with extrarenal manifestations in the form of intravascular cardiac lipoprotein deposition.

Original language	English (US)
Pages (from-to)	6-9
Number of pages	4
Journal	Cardiovascular Pathology
Volume	42
DOIs	https://doi.org/10.1016/j.carpath.2019.04.006
State	Published - Sep 1 2019

Keywords

Emboli
Genetic
Lipid

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.carpath.2019.04.006

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title = "Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy",

abstract = "Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any other organ. Herein we present the first recognized case with extrarenal manifestations in the form of intravascular cardiac lipoprotein deposition.",

keywords = "Emboli, Genetic, Lipid",

author = "Morris, {Catherine S.} and Bois, {Melanie C.} and Aust, {Charles H.} and Ryan Thomas and Sanjeev Sethi and Maleszewski, {Joseph J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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doi = "10.1016/j.carpath.2019.04.006",

language = "English (US)",

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T2 - extrarenal manifestation of lipoprotein glomerulopathy

AU - Morris, Catherine S.

AU - Bois, Melanie C.

AU - Aust, Charles H.

AU - Thomas, Ryan

AU - Sethi, Sanjeev

AU - Maleszewski, Joseph J.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any other organ. Herein we present the first recognized case with extrarenal manifestations in the form of intravascular cardiac lipoprotein deposition.

AB - Intracapillary lipoprotein thrombi are a distinct histopathologic finding described in the setting of lipoprotein glomerulopathy. The disease is associated with mutations in the apolipoprotein E gene and responds well to lipid-lowering treatments. Lipoprotein glomerulopathy is thought to primarily affect the kidneys, and lipoprotein thrombi have never been described in any other organ. Herein we present the first recognized case with extrarenal manifestations in the form of intravascular cardiac lipoprotein deposition.

KW - Emboli

KW - Genetic

KW - Lipid

UR - http://www.scopus.com/inward/record.url?scp=85066337234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066337234&partnerID=8YFLogxK

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M3 - Article

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AN - SCOPUS:85066337234

SN - 1054-8807

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SP - 6

EP - 9

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

ER -

Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy

Abstract

Keywords

ASJC Scopus subject areas

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