Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Ashley S. Felix; Mia M. Gaudet; Carlo La Vecchia; Christina M. Nagle; Xiao Ou Shu; Elisabete Weiderpass; Hans Olov Adami; Shirley Beresford; Leslie Bernstein; Chu Chen; Linda S. Cook; Immaculata De Vivo; Jennifer A. Doherty; Christine M. Friedenreich; Susan M. Gapstur; Dierdre Hill; Pamela L. Horn-Ross; James V. Lacey; Fabio Levi; Xiaolin Liang; Lingeng Lu; Anthony Magliocco; Susan E. McCann; Eva Negri; Sara H. Olson; Julie R. Palmer; Alpa V. Patel; Stacey Petruzella; Jennifer Prescott; Harvey A. Risch; Lynn Rosenberg; Mark E. Sherman; Amanda B. Spurdle; Penelope M. Webb; Lauren A. Wise; Yong Bing Xiang; Wanghong Xu; Hannah P. Yang; Herbert Yu; Anne Zeleniuch-Jacquotte; Louise A. Brinton

doi:10.1002/ijc.29229

Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Ashley S. Felix, Mia M. Gaudet, Carlo La Vecchia, Christina M. Nagle, Xiao Ou Shu, Elisabete Weiderpass, Hans Olov Adami, Shirley Beresford, Leslie Bernstein, Chu Chen, Linda S. Cook, Immaculata De Vivo, Jennifer A. Doherty, Christine M. Friedenreich, Susan M. Gapstur, Dierdre Hill, Pamela L. Horn-Ross, James V. Lacey, Fabio Levi, Xiaolin LiangLingeng Lu, Anthony Magliocco, Susan E. McCann, Eva Negri, Sara H. Olson, Julie R. Palmer, Alpa V. Patel, Stacey Petruzella, Jennifer Prescott, Harvey A. Risch, Lynn Rosenberg, Mark E. Sherman, Amanda B. Spurdle, Penelope M. Webb, Lauren A. Wise, Yong Bing Xiang, Wanghong Xu, Hannah P. Yang, Herbert Yu, Anne Zeleniuch-Jacquotte, Louise A. Brinton

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR=0.81, 95% CI=0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR=0.69, 95% CI=0.58-0.82), older age at first use (≥35 years pooled-OR=0.53, 95% CI=0.43-0.67), older age at last use (≥45 years pooled-OR=0.60, 95% CI=0.50-0.72), longer duration of use (≥10 years pooled-OR=0.61, 95% CI=0.52-0.71) and recent use (within 1 year of study entry pooled-OR=0.39, 95% CI=0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.

Original language	English (US)
Pages (from-to)	E410-E422
Journal	International Journal of Cancer
Volume	136
Issue number	5
DOIs	https://doi.org/10.1002/ijc.29229
State	Published - Mar 1 2015

Keywords

Contraception
Endometrial neoplasm
Etiology
Pooled analysis

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/ijc.29229

Cite this

Felix, A. S., Gaudet, M. M., La Vecchia, C., Nagle, C. M., Shu, X. O., Weiderpass, E., Adami, H. O., Beresford, S., Bernstein, L., Chen, C., Cook, L. S., De Vivo, I., Doherty, J. A., Friedenreich, C. M., Gapstur, S. M., Hill, D., Horn-Ross, P. L., Lacey, J. V., Levi, F., ... Brinton, L. A. (2015). Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium. International Journal of Cancer, 136(5), E410-E422. https://doi.org/10.1002/ijc.29229

Felix, AS, Gaudet, MM, La Vecchia, C, Nagle, CM, Shu, XO, Weiderpass, E, Adami, HO, Beresford, S, Bernstein, L, Chen, C, Cook, LS, De Vivo, I, Doherty, JA, Friedenreich, CM, Gapstur, SM, Hill, D, Horn-Ross, PL, Lacey, JV, Levi, F, Liang, X, Lu, L, Magliocco, A, McCann, SE, Negri, E, Olson, SH, Palmer, JR, Patel, AV, Petruzella, S, Prescott, J, Risch, HA, Rosenberg, L, Sherman, ME, Spurdle, AB, Webb, PM, Wise, LA, Xiang, YB, Xu, W, Yang, HP, Yu, H, Zeleniuch-Jacquotte, A & Brinton, LA 2015, 'Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium', International Journal of Cancer, vol. 136, no. 5, pp. E410-E422. https://doi.org/10.1002/ijc.29229

@article{8d531958a45142bda50c2f831d41c942,

title = "Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium",

abstract = "Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR=0.81, 95% CI=0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR=0.69, 95% CI=0.58-0.82), older age at first use (≥35 years pooled-OR=0.53, 95% CI=0.43-0.67), older age at last use (≥45 years pooled-OR=0.60, 95% CI=0.50-0.72), longer duration of use (≥10 years pooled-OR=0.61, 95% CI=0.52-0.71) and recent use (within 1 year of study entry pooled-OR=0.39, 95% CI=0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.",

keywords = "Contraception, Endometrial neoplasm, Etiology, Pooled analysis",

author = "Felix, {Ashley S.} and Gaudet, {Mia M.} and {La Vecchia}, Carlo and Nagle, {Christina M.} and Shu, {Xiao Ou} and Elisabete Weiderpass and Adami, {Hans Olov} and Shirley Beresford and Leslie Bernstein and Chu Chen and Cook, {Linda S.} and {De Vivo}, Immaculata and Doherty, {Jennifer A.} and Friedenreich, {Christine M.} and Gapstur, {Susan M.} and Dierdre Hill and Horn-Ross, {Pamela L.} and Lacey, {James V.} and Fabio Levi and Xiaolin Liang and Lingeng Lu and Anthony Magliocco and McCann, {Susan E.} and Eva Negri and Olson, {Sara H.} and Palmer, {Julie R.} and Patel, {Alpa V.} and Stacey Petruzella and Jennifer Prescott and Risch, {Harvey A.} and Lynn Rosenberg and Sherman, {Mark E.} and Spurdle, {Amanda B.} and Webb, {Penelope M.} and Wise, {Lauren A.} and Xiang, {Yong Bing} and Wanghong Xu and Yang, {Hannah P.} and Herbert Yu and Anne Zeleniuch-Jacquotte and Brinton, {Louise A.}",

note = "Publisher Copyright: {\textcopyright} 2014 UICC.",

year = "2015",

month = mar,

day = "1",

doi = "10.1002/ijc.29229",

language = "English (US)",

volume = "136",

pages = "E410--E422",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

number = "5",

}

TY - JOUR

T1 - Intrauterine devices and endometrial cancer risk

T2 - A pooled analysis of the Epidemiology of Endometrial Cancer Consortium

AU - Felix, Ashley S.

AU - Gaudet, Mia M.

AU - La Vecchia, Carlo

AU - Nagle, Christina M.

AU - Shu, Xiao Ou

AU - Weiderpass, Elisabete

AU - Adami, Hans Olov

AU - Beresford, Shirley

AU - Bernstein, Leslie

AU - Chen, Chu

AU - Cook, Linda S.

AU - De Vivo, Immaculata

AU - Doherty, Jennifer A.

AU - Friedenreich, Christine M.

AU - Gapstur, Susan M.

AU - Hill, Dierdre

AU - Horn-Ross, Pamela L.

AU - Lacey, James V.

AU - Levi, Fabio

AU - Liang, Xiaolin

AU - Lu, Lingeng

AU - Magliocco, Anthony

AU - McCann, Susan E.

AU - Negri, Eva

AU - Olson, Sara H.

AU - Palmer, Julie R.

AU - Patel, Alpa V.

AU - Petruzella, Stacey

AU - Prescott, Jennifer

AU - Risch, Harvey A.

AU - Rosenberg, Lynn

AU - Sherman, Mark E.

AU - Spurdle, Amanda B.

AU - Webb, Penelope M.

AU - Wise, Lauren A.

AU - Xiang, Yong Bing

AU - Xu, Wanghong

AU - Yang, Hannah P.

AU - Yu, Herbert

AU - Zeleniuch-Jacquotte, Anne

AU - Brinton, Louise A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR=0.81, 95% CI=0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR=0.69, 95% CI=0.58-0.82), older age at first use (≥35 years pooled-OR=0.53, 95% CI=0.43-0.67), older age at last use (≥45 years pooled-OR=0.60, 95% CI=0.50-0.72), longer duration of use (≥10 years pooled-OR=0.61, 95% CI=0.52-0.71) and recent use (within 1 year of study entry pooled-OR=0.39, 95% CI=0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.

AB - Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR=0.81, 95% CI=0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR=0.69, 95% CI=0.58-0.82), older age at first use (≥35 years pooled-OR=0.53, 95% CI=0.43-0.67), older age at last use (≥45 years pooled-OR=0.60, 95% CI=0.50-0.72), longer duration of use (≥10 years pooled-OR=0.61, 95% CI=0.52-0.71) and recent use (within 1 year of study entry pooled-OR=0.39, 95% CI=0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes.

KW - Contraception

KW - Endometrial neoplasm

KW - Etiology

KW - Pooled analysis

UR - http://www.scopus.com/inward/record.url?scp=84918828502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918828502&partnerID=8YFLogxK

U2 - 10.1002/ijc.29229

DO - 10.1002/ijc.29229

M3 - Article

C2 - 25242594

AN - SCOPUS:84918828502

SN - 0020-7136

VL - 136

SP - E410-E422

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 5

ER -

Intrauterine devices and endometrial cancer risk: A pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this