Intrathoracic Manifestations in Mixed Connective Tissue Disease

UDAYA B.S. PRAKASH, HARVINDER S. LUTHRA, MATTHEW B. DIVERTIE

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63 Scopus citations

Abstract

A high frequency of occurrence of pleuropulmonary manifestations in mixed connective tissue disease (MCTD) has been reported in the literature. A retrospective analysis of 81 adult patients with the diagnosis of MCTD who were examined at our medical center from 1973 through 1977 revealed that pleuropulmonary involvement occurred in 20 (25%). Thirteen patients (16%) had dyspnea, six (7%) had chest pain, and four (5%) had cough. Chest roentgenograms disclosed basal interstitial processes in 15 patients (19%), pleural effusion in 5 (6%), pneumonic infiltrates in 3 (4%), and pleural thickening in 2 (2%). Ahnormalities of pulmonary function were noted in 9 (69%) of 13 patients tested, and esophagographic abnormalities were present in 19 (53%) of 36 patients tested. Systemic corticosteroid therapy was beneficial in two of the eight patients so treated, and nonsteroidal anti-inflammatory drugs resolved most of the clinical features in four of the seven patients so treated. Six patients died during a 5-year follow-up period.

Original languageEnglish (US)
Pages (from-to)813-821
Number of pages9
JournalMayo Clinic proceedings
Volume60
Issue number12
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

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    PRAKASH, UDAYA. B. S., LUTHRA, HARVINDER. S., & DIVERTIE, MATTHEW. B. (1985). Intrathoracic Manifestations in Mixed Connective Tissue Disease. Mayo Clinic proceedings, 60(12), 813-821. https://doi.org/10.1016/S0025-6196(12)64786-7