Intrarenal insulin-like growth factor-1 axis after unilateral nephrectomy in rat

Fernando Custodio Fervenza, Tanny Tsao, Fay Hsu, Ralph Rabkin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

It has been suggested that insulin-like growth factor-1 (IGF-1) may play a role in early compensatory renal growth. Since IGF-1 action is influenced by IGF binding proteins (IGFBP), this study was conducted to characterize the changes in gene expression not only of IGF-1 and its receptor, but also of IGFBP in the hypertrophying kidney of adult and weanling rats 1 wk after removal of the other kidney. At this time, there were distinct age-dependent changes in the renal IGF-1 axis. In the mature kidney, IGF-1 mRNA levels fell without a change in kidney IGF-1 peptide content. Likewise, although IGFBP- 2, -3, and -5 mRNA levels fell, membrane-associated IGFBP did not change. IGF-1 receptor mRNA levels and IGF-1 receptor number both fell. In the weanling kidneys, IGF-1 mRNA and peptide levels and IGF-1 receptor binding were unaltered. However, IGFBP-3, -4, and -5 mRNA levels were increased, as were plasma membrane-associated IGFBP. Although these changes in the intrarenal IGF-1 axis were distinct, it is difficult to conceive how in either the mature or immature rat they could contribute to the ongoing compensatory renal growth that occurs 1 wk after loss of kidney mass unless IGF-1 were acting in a synergistic manner with other growth promoters.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalJournal of the American Society of Nephrology
Volume10
Issue number1
StatePublished - Jan 1999
Externally publishedYes

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Somatomedins
Nephrectomy
Kidney
Insulin-Like Growth Factor Binding Proteins
Somatomedin Receptors
Messenger RNA
Insulin-Like Growth Factor Binding Protein 3
Membrane Proteins
Growth
Insulin-Like Growth Factor Binding Protein 4
Insulin-Like Growth Factor Binding Protein 2
Peptides
Cell Membrane
Gene Expression

ASJC Scopus subject areas

  • Nephrology

Cite this

Intrarenal insulin-like growth factor-1 axis after unilateral nephrectomy in rat. / Fervenza, Fernando Custodio; Tsao, Tanny; Hsu, Fay; Rabkin, Ralph.

In: Journal of the American Society of Nephrology, Vol. 10, No. 1, 01.1999, p. 43-50.

Research output: Contribution to journalArticle

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