Intraoperative radiotherapy in the multimodality approach to colorectal cancer

Dieter Hahnloser, Michael G. Haddock, Heidi Nelson

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


The addition of intraoperative radiotherapy (IORT) to the multimodality approach for the treatment of locally advanced and locally recurrent colorectal cancer seems to result in improvements in local control and long-term survival. Local control and survival are most likely in patients in whom a gross total resection is accomplished. Peripheral nerve is the dose-limiting structure for patients treated with IORT. Further improvements in local control require the addition of dose modifiers during external beam radiotherapy or IORT. Distant relapse remains problematic, and effective systemic therapy is necessary to significantly improve long-term survival.

Original languageEnglish (US)
Pages (from-to)993-1013
Number of pages21
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Surgery
  • Oncology


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