TY - JOUR
T1 - Intraoperative radiation therapy for breast cancer patients
T2 - Current perspectives
AU - Dutta, Sunil W.
AU - Showalter, Shayna L.
AU - Showalter, Timothy N.
AU - Libby, Bruce
AU - Trifiletti, Daniel M.
N1 - Publisher Copyright:
© 2017 Dutta et al.
PY - 2017/4/18
Y1 - 2017/4/18
N2 - Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience.
AB - Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience.
KW - Breast conservation
KW - Electron
KW - Evidence
KW - IORT
KW - Lumpectomy
KW - Photon
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U2 - 10.2147/BCTT.S112516
DO - 10.2147/BCTT.S112516
M3 - Article
AN - SCOPUS:85020053964
SN - 1179-1314
VL - 9
SP - 257
EP - 263
JO - Breast Cancer: Targets and Therapy
JF - Breast Cancer: Targets and Therapy
ER -