Intraocular involvement of Mantle cell lymphoma: A case report and literature review

Madiha Iqbal, Yennifer Gil Castano, Taimur Sher, Mohamed A. Kharfan-Dabaja

Research output: Contribution to journalArticlepeer-review


Lymphomatous involvement of the ocular adnexal region (OAR) is generally rare; however, it constitutes the most common ocular malignancy. Most cases of ocular adnexal lymphomas are extra nodal marginal zone B cell lymphomas. Mantle cell lymphoma involvement (MCL) of the OAR is a less common presentation compared with other lymphomas and it has been reported anecdotally. Studies have suggested an association of OAR involvement with poor prognosis. Here, we report the case of a 61 year old man who started experiencing conjunctival erythema which was followed by development of bilateral proptosis. The diagnosis of Stage IV Mantle cell lymphoma with OAR involvement was confirmed 5 months after patient onset of symptomatology. He underwent treatment with systemic chemotherapy, which was followed by high-dose chemotherapy and autologous hematopoietic cell transplant. He is currently day +100 from his transplant and is in complete remission. A review of the literature regarding ocular involvement of MCL is also summarized.

Original languageEnglish (US)
JournalHematology/ Oncology and Stem Cell Therapy
StatePublished - Jan 1 2019


  • Mantle cell lymphoma involvement
  • Ocular adnexal region

ASJC Scopus subject areas

  • Hematology
  • Oncology

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