Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration.

J. Schulman, G. A. Peyman, M. B. Horton, J. Liu, R. Fiscella, Jose S Pulido, J. C. Barber, P. de Miranda

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Clearance studies in rabbits following intravitreal injection of 400 micrograms of 9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl) guanine demonstrated levels of the antiviral at 60 hours above the in vitro ID50 for several strains of human cytomegalovirus. Intravitreal administration of this new antiviral may have therapeutic application in the treatment of acute retinal necrosis and cytomegalovirus retinitis complicating acquired immune deficiency syndrome (AIDS).

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalOphthalmic Surgery
Volume17
Issue number7
StatePublished - Jul 1986
Externally publishedYes

Fingerprint

Guanine
Antiviral Agents
Acute Retinal Necrosis Syndrome
Cytomegalovirus Retinitis
Intravitreal Injections
Cytomegalovirus
Acquired Immunodeficiency Syndrome
Rabbits
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Schulman, J., Peyman, G. A., Horton, M. B., Liu, J., Fiscella, R., Pulido, J. S., ... de Miranda, P. (1986). Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration. Ophthalmic Surgery, 17(7), 429-432.

Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration. / Schulman, J.; Peyman, G. A.; Horton, M. B.; Liu, J.; Fiscella, R.; Pulido, Jose S; Barber, J. C.; de Miranda, P.

In: Ophthalmic Surgery, Vol. 17, No. 7, 07.1986, p. 429-432.

Research output: Contribution to journalArticle

Schulman, J, Peyman, GA, Horton, MB, Liu, J, Fiscella, R, Pulido, JS, Barber, JC & de Miranda, P 1986, 'Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration.', Ophthalmic Surgery, vol. 17, no. 7, pp. 429-432.
Schulman, J. ; Peyman, G. A. ; Horton, M. B. ; Liu, J. ; Fiscella, R. ; Pulido, Jose S ; Barber, J. C. ; de Miranda, P. / Intraocular 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine levels after intravitreal and subconjunctival administration. In: Ophthalmic Surgery. 1986 ; Vol. 17, No. 7. pp. 429-432.
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