Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control

Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Gary S. Stein

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations

Abstract

The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

Original languageEnglish (US)
Pages (from-to)43363-43366
Number of pages4
JournalJournal of Biological Chemistry
Volume279
Issue number42
DOIs
StatePublished - Oct 15 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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