Intranuclear trafficking

Organization and assembly of regulatory machinery for combinatorial biological control

Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Jane B. Lian, Andre J van Wijnen, Gary S. Stein

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

Original languageEnglish (US)
Pages (from-to)43363-43366
Number of pages4
JournalJournal of Biological Chemistry
Volume279
Issue number42
DOIs
StatePublished - Oct 15 2004
Externally publishedYes

Fingerprint

Machinery
Gene expression
Gene Expression
Proteins
Protein Transport
Cues
Transcription Factors
Logistics
DNA

ASJC Scopus subject areas

  • Biochemistry

Cite this

Zaidi, S. K., Young, D. W., Choi, J. Y., Pratap, J., Javed, A., Montecino, M., ... Stein, G. S. (2004). Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control. Journal of Biological Chemistry, 279(42), 43363-43366. https://doi.org/10.1074/jbc.R400020200

Intranuclear trafficking : Organization and assembly of regulatory machinery for combinatorial biological control. / Zaidi, Sayyed K.; Young, Daniel W.; Choi, Je Yong; Pratap, Jitesh; Javed, Amjad; Montecino, Martin; Stein, Janet L.; Lian, Jane B.; van Wijnen, Andre J; Stein, Gary S.

In: Journal of Biological Chemistry, Vol. 279, No. 42, 15.10.2004, p. 43363-43366.

Research output: Contribution to journalArticle

Zaidi, SK, Young, DW, Choi, JY, Pratap, J, Javed, A, Montecino, M, Stein, JL, Lian, JB, van Wijnen, AJ & Stein, GS 2004, 'Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control', Journal of Biological Chemistry, vol. 279, no. 42, pp. 43363-43366. https://doi.org/10.1074/jbc.R400020200
Zaidi, Sayyed K. ; Young, Daniel W. ; Choi, Je Yong ; Pratap, Jitesh ; Javed, Amjad ; Montecino, Martin ; Stein, Janet L. ; Lian, Jane B. ; van Wijnen, Andre J ; Stein, Gary S. / Intranuclear trafficking : Organization and assembly of regulatory machinery for combinatorial biological control. In: Journal of Biological Chemistry. 2004 ; Vol. 279, No. 42. pp. 43363-43366.
@article{08fc07aaff134f0db03e42ce08b9c486,
title = "Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control",
abstract = "The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.",
author = "Zaidi, {Sayyed K.} and Young, {Daniel W.} and Choi, {Je Yong} and Jitesh Pratap and Amjad Javed and Martin Montecino and Stein, {Janet L.} and Lian, {Jane B.} and {van Wijnen}, {Andre J} and Stein, {Gary S.}",
year = "2004",
month = "10",
day = "15",
doi = "10.1074/jbc.R400020200",
language = "English (US)",
volume = "279",
pages = "43363--43366",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "42",

}

TY - JOUR

T1 - Intranuclear trafficking

T2 - Organization and assembly of regulatory machinery for combinatorial biological control

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Choi, Je Yong

AU - Pratap, Jitesh

AU - Javed, Amjad

AU - Montecino, Martin

AU - Stein, Janet L.

AU - Lian, Jane B.

AU - van Wijnen, Andre J

AU - Stein, Gary S.

PY - 2004/10/15

Y1 - 2004/10/15

N2 - The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

AB - The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

UR - http://www.scopus.com/inward/record.url?scp=6344287907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6344287907&partnerID=8YFLogxK

U2 - 10.1074/jbc.R400020200

DO - 10.1074/jbc.R400020200

M3 - Article

VL - 279

SP - 43363

EP - 43366

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 42

ER -