Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression

Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. Van Wijnen, Martin Montecino, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The architecturally associated subnuclear organization of nucleic acids and cognate regulatory factors suggest functional interrelationships between nuclear structure and gene expression. Mechanisms that contribute to the spatial distribution of transcription factors within the three-dimensional context of nuclear architecture control the sorting of regulatory information as well as the assembly and activities of sites within the nucleus that support gene expression. Vitamin D control of gene expression serves as a paradigm for experimentally addressing mechanisms that govern the intranuclear targeting of regulatory factors to nuclear domains where transcription of developmental and tissue-specific genes occur. We will present an overview of molecular, cellular, genetic, and biochemical approaches that provide insight into the trafficking of regulatory factors that mediate vitamin D control of gene expression to transcriptionally active subnuclear sites. Examples will be presented that suggest modifications in the intranuclear targeting of transcription factors abrogate competency for vitamin D control of skeletal gene expression during development and fidelity of gene expression in tumor cells.

Original languageEnglish (US)
Pages (from-to)340-355
Number of pages16
JournalJournal of cellular biochemistry
Volume88
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Nuclear matrix
  • Osteocalcin
  • RUNX/cbfa/AML
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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