Intranuclear trafficking of transcription factors: Implications for biological control

G. S. Stein, A. J. van Wijnen, J. L. Stein, J. B. Lian, M. Montecino, J. Y. Choi, K. Zaidi, A. Javed

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71 Scopus citations

Abstract

The subnuclear organization of nucleic acids and cognate regulatory factors suggests that there are functional interrelationships between nuclear structure and gene expression. Nuclear proteins that are localized in discrete domains within the nucleus include the leukemia-associated acute myelogenous leukemia (AML) and promyelocytic leukemia (PML) factors, the SC-35 RNA-processing factors, nucleolar proteins and components of both transcriptional and DNA replication complexes. Mechanisms that control the spatial distribution of transcription factors within the three-dimensional context of the nucleus may involve the sorting of regulatory information, as well as contribute to the assembly and activity of sites that support gene expression. Molecular, cellular, genetic and biochemical approaches have identified distinct protein segments, termed intranuclear-targeting signals, that are responsible for directing regulatory factors to specific subnuclear sites. Gene rearrangements that remove or alter intranuclear-targeting signals are prevalent in leukemias and have been linked to altered localization of regulatory factors within the nucleus. These modifications in the intranuclear targeting of transcription factors might abrogate fidelity of gene expression in tumor cells by influencing the spatial organization and/or assembly of machineries involved in the synthesis and processing of gene transcripts.

Original languageEnglish (US)
Pages (from-to)2527-2533
Number of pages7
JournalJournal of cell science
Volume113
Issue number14
StatePublished - Aug 14 2000

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Keywords

  • AML/CBFA
  • Chromatin
  • Gene expression
  • Nuclear matrix
  • Nuclear structure
  • Subnuclear domain

ASJC Scopus subject areas

  • Cell Biology

Cite this

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Montecino, M., Choi, J. Y., Zaidi, K., & Javed, A. (2000). Intranuclear trafficking of transcription factors: Implications for biological control. Journal of cell science, 113(14), 2527-2533.