Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

Gary S. Stein; Jane B. Lian; Janet L. Stein; André J. Van Wijnen; Martin Montecino; Jitesh Pratap; Je Choi; S. Kaleem Zaidi; Amjad Javed; Soraya Gutierrez; Kimberly Harrington; Jiali Shen; Daniel Young

doi:10.1016/S1079-9796(03)00029-9

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. Van Wijnen, Martin Montecino, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Amjad Javed, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young

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Abstract

RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

Original language	English (US)
Pages (from-to)	170-176
Number of pages	7
Journal	Blood Cells, Molecules, and Diseases
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S1079-9796(03)00029-9
State	Published - 2003

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Hematology
Cell Biology

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Stein, G. S., Lian, J. B., Stein, J. L., Van Wijnen, A. J., Montecino, M., Pratap, J., Choi, J., Zaidi, S. K., Javed, A., Gutierrez, S., Harrington, K., Shen, J., & Young, D. (2003). Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer. Blood Cells, Molecules, and Diseases, 30(2), 170-176. https://doi.org/10.1016/S1079-9796(03)00029-9

Stein, GS, Lian, JB, Stein, JL, Van Wijnen, AJ, Montecino, M, Pratap, J, Choi, J, Zaidi, SK, Javed, A, Gutierrez, S, Harrington, K, Shen, J & Young, D 2003, 'Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer', Blood Cells, Molecules, and Diseases, vol. 30, no. 2, pp. 170-176. https://doi.org/10.1016/S1079-9796(03)00029-9

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title = "Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer",

abstract = "RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.",

author = "Stein, {Gary S.} and Lian, {Jane B.} and Stein, {Janet L.} and {Van Wijnen}, {Andr{\'e} J.} and Martin Montecino and Jitesh Pratap and Je Choi and Zaidi, {S. Kaleem} and Amjad Javed and Soraya Gutierrez and Kimberly Harrington and Jiali Shen and Daniel Young",

note = "Funding Information: Studies reported were in part supported by grants from the National Institutes of Health (AR45688, PO1CA82834, DE12528, AR39588, AR45689, PO1AR48818). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. The authors thank Elizabeth Bronstein for editorial assistance with preparation of the manuscript. This paper is based on a presentation at a Focused Workshop on “Transcriptional Regulation RUNX Proteins in Development and Leukemia” held at the University of Virginia, August 25–27, 2002, sponsored by The Leukemia & Lymphoma Society.",

year = "2003",

doi = "10.1016/S1079-9796(03)00029-9",

language = "English (US)",

volume = "30",

pages = "170--176",

journal = "Blood Cells, Molecules, and Diseases",

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AU - Stein, Gary S.

AU - Lian, Jane B.

AU - Stein, Janet L.

AU - Van Wijnen, André J.

AU - Montecino, Martin

AU - Pratap, Jitesh

AU - Choi, Je

AU - Zaidi, S. Kaleem

AU - Javed, Amjad

AU - Gutierrez, Soraya

AU - Harrington, Kimberly

AU - Shen, Jiali

AU - Young, Daniel

N1 - Funding Information: Studies reported were in part supported by grants from the National Institutes of Health (AR45688, PO1CA82834, DE12528, AR39588, AR45689, PO1AR48818). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. The authors thank Elizabeth Bronstein for editorial assistance with preparation of the manuscript. This paper is based on a presentation at a Focused Workshop on “Transcriptional Regulation RUNX Proteins in Development and Leukemia” held at the University of Virginia, August 25–27, 2002, sponsored by The Leukemia & Lymphoma Society.

PY - 2003

Y1 - 2003

N2 - RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

AB - RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

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Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

Abstract

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