Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis

Jens U. Ponikau, David A. Sherris, Hirohito Kita, Eugene B. Kern

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

Background: Chronic rhinosinusitis (CRS) is the most common chronic disease that is frequently refractory to treatment. Objective: We sought to establish the safety and demonstrate the clinical efficacy of intranasai antifungal drug therapy in patients with CRS in a pilot trial. Methods: A prospective open-label trial used amphotericin B as a medical treatment in 51 randomly selected patients with CRS. The antifungal agent was applied intranasaily as 20 mL of a 100 μg/mL solution twice daily. The outcome was measured by using their symptoms and by using an endoscopic scoring system in all patients. In addition, pretreatment and posttreatment coronal computed tomographic scans of the nose and sinuses were available for evaluation in 13 patients. Results: By using amphotericin B, improvement of sinusitis symptoms was observed in 38 (75%) of 51 patients. Endoscopically, 18 (35%) of 51 patients became disease free, and an additional 20 (39%) of 51 had improvement of at least one stage (P < .001). No effect was seen in 13 (25%) of 51 patients. The available computed tomographic scans before and after treatment demonstrated a significant reduction in the inflammatory mucosa thickening that had occluded the paranasal sinuses (P < .0001 in maxillary sinus). Conclusion: This open-label pilot trial demonstrates that direct mucoadministration of an antifungal drug appears to be both safe and effective in the treatment of patients with CRS. Therefore controlled and blinded trials are indicated to clarify the novel role of intranasal antifungal drugs in the treatment of CRS.

Original languageEnglish (US)
Pages (from-to)862-866
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume110
Issue number6
DOIs
StatePublished - Dec 1 2002

Keywords

  • Antifungal
  • Chronic sinusitis
  • Eosinophils
  • Nasal polyps
  • Rhinosinusitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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