Intramyocellular lipids: Maker vs. marker of insulin resistance

ZengKui Guo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Intramyocellular triglyceride (imcTG) content in skeletal muscle is abnormally high in lipid oversupply models in obesity, type 2 diabetes (T2D) and other metabolically diseased conditions. The imcTG abnormality was also found to be significantly correlated with muscle insulin resistance (MIR). As skeletal muscle is the main site for insulin-mediated glucose utilization, the research on this topic has been active since. However, to date the pathways responsible for the imcTG excess and the mechanisms underlying the imcTG-MIR correlation have not been identified. A current view is focused on a backward mechanism that fatty acid oxidation by muscle is impaired causing imcTG to accumulate and, therefore, an enlarged imcTG pool is merely a marker of MIR. However, based on kinetic studies, it is more likely that imcTG is a source of MIR. On one hand, an enlarged and fast turning over imcTG pool interferes with insulin signaling by producing excess amounts of signaling molecules that activate PKC pathways. On the other hand, it may promote mitochondrial β-oxidation that suppresses glucose metabolism via substrate competition. Therefore, it is hypothesized that imcTG is a source of MIR.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalMedical Hypotheses
Volume70
Issue number3
DOIs
StatePublished - 2008

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Insulin Resistance
Triglycerides
Lipids
Muscles
Skeletal Muscle
Insulin
Glucose
Type 2 Diabetes Mellitus
Fatty Acids
Obesity
Research

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Intramyocellular lipids : Maker vs. marker of insulin resistance. / Guo, ZengKui.

In: Medical Hypotheses, Vol. 70, No. 3, 2008, p. 625-629.

Research output: Contribution to journalArticle

Guo, ZengKui. / Intramyocellular lipids : Maker vs. marker of insulin resistance. In: Medical Hypotheses. 2008 ; Vol. 70, No. 3. pp. 625-629.
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