Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT

Yue Dong, Patricia E. Beighley, Diane R. Eaker, Mair Zamir, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil® contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R 2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
DOIs
StatePublished - Jun 2 2008
EventMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6916
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Keywords

  • Blood volume
  • Electron beam computed tomography
  • Heterogeneity
  • Micro-ct
  • Microcirculation
  • Myocardium
  • Sub-resolution

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT'. Together they form a unique fingerprint.

  • Cite this

    Dong, Y., Beighley, P. E., Eaker, D. R., Zamir, M., & Ritman, E. L. (2008). Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT. In Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images [691624] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6916). https://doi.org/10.1117/12.772713