Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT

Yue Dong; Patricia E. Beighley; Diane R. Eaker; Mair Zamir; Erik L. Ritman

doi:10.1117/12.772713

Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT

Yue Dong, Patricia E. Beighley, Diane R. Eaker, Mair Zamir, Erik L. Ritman

Physiology & Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F^1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil® contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R ² =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

Original language	English (US)
Title of host publication	Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images
DOIs	https://doi.org/10.1117/12.772713
State	Published - 2008
Event	Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States Duration: Feb 17 2008 → Feb 19 2008

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6916
ISSN (Print)	1605-7422

Other

Other	Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images
Country/Territory	United States
City	San Diego, CA
Period	2/17/08 → 2/19/08

Keywords

Blood volume
Electron beam computed tomography
Heterogeneity
Micro-ct
Microcirculation
Myocardium
Sub-resolution

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

Access to Document

10.1117/12.772713

Cite this

Dong, Y., Beighley, P. E., Eaker, D. R., Zamir, M., & Ritman, E. L. (2008). Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT. In Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images Article 691624 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6916). https://doi.org/10.1117/12.772713

Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT. / Dong, Yue; Beighley, Patricia E.; Eaker, Diane R. et al.
Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images. 2008. 691624 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6916).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dong, Y, Beighley, PE, Eaker, DR, Zamir, M & Ritman, EL 2008, Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT. in Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images., 691624, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6916, Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/17/08. https://doi.org/10.1117/12.772713

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title = "Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT",

abstract = "Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil{\textregistered} contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R 2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.",

keywords = "Blood volume, Electron beam computed tomography, Heterogeneity, Micro-ct, Microcirculation, Myocardium, Sub-resolution",

author = "Yue Dong and Beighley, {Patricia E.} and Eaker, {Diane R.} and Mair Zamir and Ritman, {Erik L.}",

year = "2008",

doi = "10.1117/12.772713",

language = "English (US)",

isbn = "9780819471000",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images",

note = "Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images ; Conference date: 17-02-2008 Through 19-02-2008",

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T1 - Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT

AU - Dong, Yue

AU - Beighley, Patricia E.

AU - Eaker, Diane R.

AU - Zamir, Mair

AU - Ritman, Erik L.

PY - 2008

Y1 - 2008

N2 - Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil® contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R 2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

AB - Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil® contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R 2 =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

KW - Blood volume

KW - Electron beam computed tomography

KW - Heterogeneity

KW - Micro-ct

KW - Microcirculation

KW - Myocardium

KW - Sub-resolution

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images

T2 - Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images

Y2 - 17 February 2008 through 19 February 2008

ER -

Intramyocardial capillary blood volume estimated by whole-body CT - Validation by micro-CT

Abstract

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Keywords

ASJC Scopus subject areas

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