Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: Expanding the spectrum of CD30-positive lymphoproliferative disorders

Mark A. Samols, Albert Su, Seong Ra, Mark A. Cappel, Abner Louissant, Ryan A. Knudson, Rhett P. Ketterling, Jonathan Said, Scott Binder, Nancy Lee Harris, Andrew L. Feldman, Jinah Kim, Youn H. Kim, Dita Gratzinger

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Intravascular large B-cell lymphomas and EBV NK/T-cell lymphomas commonly follow an aggressive clinical course. We recently reported an entirely intravascular anaplastic large cell lymphoma (ALCL) in the skin with a surprisingly indolent clinical course; interestingly, this lymphoma involved the lymphatic rather than the blood vasculature. We hypothesized that intravascular skin-limited ALCL is distinct from aggressive systemic intravascular lymphomas in its intralymphatic localization and clinical course. We now describe 18 cases of cutaneous intravascular large cell lymphoproliferations from 4 institutions. All 12 intravascular large T-cell lesions were intralymphatic; the majority (9) were CD30 T-cell lymphoproliferative disorders (TLPDs), 5 further classified as intravascular ALK ALCL. One ALK ALCL and 2 benign microscopic intravascular T-cell proliferations were also intralymphatic. A single case of otherwise typical cutaneous follicle center lymphoma contained intralymphatic centroblasts. The clinical and pathologic characteristics of the CD30 TLPDs were similar to those of their extravascular counterparts, including extralymphatic dermal involvement in a subset, DUSP22-IRF4 translocations in half of tested ALK ALCLs, and associated mycosis fungoides in 1; most were skin-limited at baseline and remained so at relapse. All 5 cases of intravascular large B-cell lymphoma involved the blood vasculature and behaved in a clinically aggressive manner; the ALK ALCL, although intralymphatic, was systemic and clinically aggressive. We propose that cutaneous ALK ALCL and related CD30 ALK TLPDs involving the lymphatics are part of an expanding spectrum of CD30 TLPDs. The identification of intralymphatic as distinct from blood vascular localization may provide critical prognostic and therapeutic information.

Original languageEnglish (US)
Pages (from-to)1203-1211
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume38
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • anaplastic large cell lymphoma
  • intravascular
  • lymphatic

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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    Samols, M. A., Su, A., Ra, S., Cappel, M. A., Louissant, A., Knudson, R. A., Ketterling, R. P., Said, J., Binder, S., Harris, N. L., Feldman, A. L., Kim, J., Kim, Y. H., & Gratzinger, D. (2014). Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: Expanding the spectrum of CD30-positive lymphoproliferative disorders. American Journal of Surgical Pathology, 38(9), 1203-1211. https://doi.org/10.1097/PAS.0000000000000217