Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?

Dominique Thabut, Vijay Shah

Research output: Contribution to journalComment/debatepeer-review

176 Scopus citations

Abstract

Portal hypertension accounts for the majority of morbidity and mortality that is encountered in patients with cirrhosis. Portal hypertension is initiated in large part through increases in intrahepatic vascular resistance. Fibrosis, regenerative nodule formation, and intrahepatic vasoconstriction are classical mechanisms that account for increased intrahepatic vascular resistance in cirrhosis. Recent data suggest that intrahepatic angiogenesis and sinusoidal remodeling could also be involved in sinusoidal resistance, fibrosis, and portal hypertension. While angiogenesis is defined as the formation of new vessels deriving from existing ones, sinusoidal remodeling in its pathological form associated with cirrhosis is characterized by increased mural coverage of vessels by contractile HSC. Most attention on the mechanisms of these processes has focused on the liver sinusoidal endothelial cell (SEC), the hepatic stellate cell (HSC), and the paracrine signaling pathways between these two cell types. Interventions that target these vascular structural changes have beneficial effects on portal hypertension and fibrosis in some animal studies which has stimulated interest for pursuing parallel studies in humans with portal hypertension.

Original languageEnglish (US)
Pages (from-to)976-980
Number of pages5
JournalJournal of hepatology
Volume53
Issue number5
DOIs
StatePublished - Nov 2010

Keywords

  • Angiogenesis
  • Cirrhosis
  • Portal hypertension
  • Receptor tyrosine kinase
  • Vascular remodeling

ASJC Scopus subject areas

  • Hepatology

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