Intraductal papillary mucinous neoplasm: did it exist prior to 1980?

Matthew K. Tollefson, Karen D. Libsch, Michael G. Sarr, Suresh T Chari, Eugene P. DiMagno, Raul Urrutia, Thomas Christopher Smyrk

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

INTRODUCTION: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas was first reported in 1982. It is not clear whether the appearance of this neoplasm is a new epidemic or an old disease previously overlooked. AIM: To determine whether IPMN existed as a separate entity before 1982. METHODOLOGY: We reviewed our pathology reports from all cases of pancreatic cancer diagnosed between 1960 and 1980. Pathologic specimens with descriptors--"mucinous," "cystic," or "papillary"--underwent histologic reexamination. Medical records for patients given a new diagnosis of IPMN from this pathologic review were assessed. RESULTS: Eighty-four of more than 4,000 pathology reports reviewed contained a key word triggering histologic review. IPMN was identified in 21 patients. Patients had a mean age of 63 years (range, 44-77 years) with symptoms present for a mean of 76 months (median, 15 months; range, 1-516 months). Reported symptoms were abdominal pain in 17, jaundice in 13, weight loss in 12, and pancreatic insufficiency in 7 patients. On pathologic review, the in situ component was graded as adenoma in 4, borderline in 4, and carcinoma in 13. Parenchymal invasion was present in 11/21 (52%). Excluding four postoperative mortalities, mean time to death was 58 months (median, 15 months; range, 2-264 months). Seven patients died of IPMN, 4 of other causes without evidence of recurrence, and 6 of unknown causes. CONCLUSIONS: IPMN existed in its current known form prior to 1982. Our study cannot determine whether the prevalence or incidence has changed since that time.

Original languageEnglish (US)
JournalPancreas
Volume26
Issue number3
StatePublished - Apr 2003

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Neoplasms
Pancreatic Neoplasms
Pathology
Exocrine Pancreatic Insufficiency
Jaundice
Adenoma
Abdominal Pain
Medical Records
Weight Loss
Carcinoma
Recurrence
Mortality
Incidence

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Tollefson, M. K., Libsch, K. D., Sarr, M. G., Chari, S. T., DiMagno, E. P., Urrutia, R., & Smyrk, T. C. (2003). Intraductal papillary mucinous neoplasm: did it exist prior to 1980? Pancreas, 26(3).

Intraductal papillary mucinous neoplasm : did it exist prior to 1980? / Tollefson, Matthew K.; Libsch, Karen D.; Sarr, Michael G.; Chari, Suresh T; DiMagno, Eugene P.; Urrutia, Raul; Smyrk, Thomas Christopher.

In: Pancreas, Vol. 26, No. 3, 04.2003.

Research output: Contribution to journalArticle

Tollefson, MK, Libsch, KD, Sarr, MG, Chari, ST, DiMagno, EP, Urrutia, R & Smyrk, TC 2003, 'Intraductal papillary mucinous neoplasm: did it exist prior to 1980?', Pancreas, vol. 26, no. 3.
Tollefson MK, Libsch KD, Sarr MG, Chari ST, DiMagno EP, Urrutia R et al. Intraductal papillary mucinous neoplasm: did it exist prior to 1980? Pancreas. 2003 Apr;26(3).
Tollefson, Matthew K. ; Libsch, Karen D. ; Sarr, Michael G. ; Chari, Suresh T ; DiMagno, Eugene P. ; Urrutia, Raul ; Smyrk, Thomas Christopher. / Intraductal papillary mucinous neoplasm : did it exist prior to 1980?. In: Pancreas. 2003 ; Vol. 26, No. 3.
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