Intracranial low-grade gliomas in adults: 30-Year experience with long-term follow-up at Mayo Clinic

David A. Schomas, Nadia N Laack, Ravi D. Rao, Fredric B. Meyer, Edward G. Shaw, Brian Patrick O'Neill, Caterina Giannini, Paul D. Brown

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The purpose of this study was to evaluate long-term survival in patients with nonpilocytic low-grade gliomas (LGGs). Records of 314 adult patients with nonpilocytic LGGs diagnosed between 1960 and 1992 at the Mayo Clinic, Rochester, Minnesota, were retrospectively reviewed. The Kaplan-Meier method estimated progression-free survival (PFS) and overall survival (OS). Median age at diagnosis was 36 years. Median follow-up was 13.6 years. Operative pathology revealed pure astrocytoma in 181 patients (58%), oligoastrocytoma in 99 (31%), and oligodendroglioma in 34 (11%). Gross total resection (GTR) was achieved in 41 patients (13%), radical subtotal resection (rSTR) in 33 (11%), subtotal resection in 130 (41%), and biopsy only in 110 (35%). Median OS was 6.9 years (range, 1 month-38.5 years). Adverse prognostic factors for OS identified by multivariate analysis were tumor size 5 cm or larger, pure astrocytoma histology, Kernohan grade 2, undergoing less than rSTR, and presentation with sensory motor symptoms. Statistically significant adverse prognostic factors for PFS by multivariate analysis were only tumor size 5 cm or larger and undergoing less than rSTR. In patients who underwent less than rSTR, radiotherapy (RT) was associated with improved OS and PFS. A substantial proportion of patients have a good long-term prognosis after GTR and rSTR, with nearly half of patients free of recurrence 10 years after diagnosis. Postoperative RT was associated with improved OS and PFS and is recommended for patients after subtotal resection or biopsy.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalNeuro-Oncology
Volume11
Issue number4
DOIs
StatePublished - Aug 2009

Fingerprint

Glioma
Disease-Free Survival
Survival
Astrocytoma
Radiotherapy
Multivariate Analysis
Biopsy
Oligodendroglioma
Survival Analysis
Neoplasms
Histology
Pathology
Recurrence

Keywords

  • Adult
  • Combined modality
  • Low-grade glioma
  • Radiation
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Intracranial low-grade gliomas in adults : 30-Year experience with long-term follow-up at Mayo Clinic. / Schomas, David A.; Laack, Nadia N; Rao, Ravi D.; Meyer, Fredric B.; Shaw, Edward G.; O'Neill, Brian Patrick; Giannini, Caterina; Brown, Paul D.

In: Neuro-Oncology, Vol. 11, No. 4, 08.2009, p. 437-445.

Research output: Contribution to journalArticle

Schomas, David A. ; Laack, Nadia N ; Rao, Ravi D. ; Meyer, Fredric B. ; Shaw, Edward G. ; O'Neill, Brian Patrick ; Giannini, Caterina ; Brown, Paul D. / Intracranial low-grade gliomas in adults : 30-Year experience with long-term follow-up at Mayo Clinic. In: Neuro-Oncology. 2009 ; Vol. 11, No. 4. pp. 437-445.
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