Intracellular signaling pathways in human eosinophil activation: Role of a β2 integrin, α(M)β2

Masahiko Kato, Hirokazu Kimura, Atsushi Tachibana, Youichi Motegi, Kenichi Tokuyama, Hirohito Kita, Akihiro Morikawa

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Cellular adhesion is crucial roles for eosinophil effector functions such as degranulation. Here, we focused on the role of a β2 integrin, α(M)β2, in intracellular signaling pathways of human eosinophil activation. We found that the ligation of α(M)β2 triggers the activation of an intracellular signaling cascade, including protein tyrosine phosphorylation and phosphoinositide turnover, and subsequent cellular degranulation in human eosinophils. These signaling events may play important roles in adhesion-dependent cellular functions of eosinophils.

Original languageEnglish (US)
Pages (from-to)51-53
Number of pages3
JournalInternational archives of allergy and immunology
Volume120
Issue numberSUPPL. 1
DOIs
StatePublished - Oct 8 1999

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Keywords

  • Adhesion
  • Eosinophil
  • Integrin
  • Signal transduction
  • Superoxide

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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