Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Nathan W Cummins, Wei Jiang, John McGinty, Gary D. Bren, Ronald J. Bosch, Alan Landay, Steven G. Deeks, Jeffrey N. Martin, Daniel Douek, Michael M. Lederman, Jason Brenchley, Andrew David Badley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalJournal of Infectious Diseases
Volume202
Issue number3
DOIs
StatePublished - Aug 1 2010

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CD4 Lymphocyte Count
T-Lymphocytes
HIV
Bacterial DNA
Caspase 8
Virus Diseases
Viral Load
Peptide Hydrolases
Cell Death
Proteins

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Medicine(all)

Cite this

Intracellular Casp8p41 content is inversely associated with CD4 T cell count. / Cummins, Nathan W; Jiang, Wei; McGinty, John; Bren, Gary D.; Bosch, Ronald J.; Landay, Alan; Deeks, Steven G.; Martin, Jeffrey N.; Douek, Daniel; Lederman, Michael M.; Brenchley, Jason; Badley, Andrew David.

In: Journal of Infectious Diseases, Vol. 202, No. 3, 01.08.2010, p. 386-391.

Research output: Contribution to journalArticle

Cummins, NW, Jiang, W, McGinty, J, Bren, GD, Bosch, RJ, Landay, A, Deeks, SG, Martin, JN, Douek, D, Lederman, MM, Brenchley, J & Badley, AD 2010, 'Intracellular Casp8p41 content is inversely associated with CD4 T cell count', Journal of Infectious Diseases, vol. 202, no. 3, pp. 386-391. https://doi.org/10.1086/653705
Cummins, Nathan W ; Jiang, Wei ; McGinty, John ; Bren, Gary D. ; Bosch, Ronald J. ; Landay, Alan ; Deeks, Steven G. ; Martin, Jeffrey N. ; Douek, Daniel ; Lederman, Michael M. ; Brenchley, Jason ; Badley, Andrew David. / Intracellular Casp8p41 content is inversely associated with CD4 T cell count. In: Journal of Infectious Diseases. 2010 ; Vol. 202, No. 3. pp. 386-391.
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