Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Nathan W. Cummins, Wei Jiang, John McGinty, Gary D. Bren, Ronald J. Bosch, Alan Landay, Steven G. Deeks, Jeffrey N. Martin, Daniel Douek, Michael M. Lederman, Jason Brenchley, Andrew D. Badley

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalJournal of Infectious Diseases
Volume202
Issue number3
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Cummins, N. W., Jiang, W., McGinty, J., Bren, G. D., Bosch, R. J., Landay, A., Deeks, S. G., Martin, J. N., Douek, D., Lederman, M. M., Brenchley, J., & Badley, A. D. (2010). Intracellular Casp8p41 content is inversely associated with CD4 T cell count. Journal of Infectious Diseases, 202(3), 386-391. https://doi.org/10.1086/653705