@article{021ff29d75f141e7a5c1e967e1012a77,
title = "Intracellular Casp8p41 content is inversely associated with CD4 T cell count",
abstract = "Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.",
author = "Cummins, {Nathan W.} and Wei Jiang and John McGinty and Bren, {Gary D.} and Bosch, {Ronald J.} and Alan Landay and Deeks, {Steven G.} and Martin, {Jeffrey N.} and Daniel Douek and Lederman, {Michael M.} and Jason Brenchley and Badley, {Andrew D.}",
note = "Funding Information: Financial support: Work on this paper was supported by the National Institutes of Health (NIH), the Center for AIDS Research, and the University of California, San Francisco (UCSF) (grants AI62261, AI40384, AI068636, U01 AI068634, P30 A127763, AI 69501, UL1 RR024131, P30 AI27763, and UL1 RR024131). Dr Nathan Cummins is supported by a Ruth L. Kirschstein National Research Service Award (award DK007013–32). This research was supported by the NIH (grant AI069994), Center for AIDS Research (grant P30 MH59037), and UCSF Clinical and Translational Research Institute Clinical Research Center (grant UL1 RR024131).",
year = "2010",
month = aug,
day = "1",
doi = "10.1086/653705",
language = "English (US)",
volume = "202",
pages = "386--391",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",
}