TY - JOUR
T1 - Intraarticular platelet-rich plasma injection in the treatment of knee osteoarthritis
T2 - Review and recommendations
AU - Pourcho, Adam M.
AU - Smith, Jay
AU - Wisniewski, Stephen J.
AU - Sellon, Jacob L.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Intraarticular platelet-rich plasma (PRP) injection has emerged as a promising treatment for knee osteoarthritis. Studies to date, including multiple randomized controlled trials, have shown that PRP is a safe and effective treatment option for knee osteoarthritis. Intraarticular PRP is similar in efficacy to hyaluronic acid, and seems to be more effective than hyaluronic acid in younger, active patients with low-grade osteoarthritis. Treatment benefits seem to wane after 6-9 mos. There are numerous PRP treatment variables that may be of importance, and the optimal PRP protocol remains unclear. Future investigations should control and analyze the effects of these variables in PRP treatment. High-quality randomized controlled trials are needed to optimize PRP treatment methods and better define the role of PRP in osteoarthritis management in the knee and, potentially, in other joints.
AB - Intraarticular platelet-rich plasma (PRP) injection has emerged as a promising treatment for knee osteoarthritis. Studies to date, including multiple randomized controlled trials, have shown that PRP is a safe and effective treatment option for knee osteoarthritis. Intraarticular PRP is similar in efficacy to hyaluronic acid, and seems to be more effective than hyaluronic acid in younger, active patients with low-grade osteoarthritis. Treatment benefits seem to wane after 6-9 mos. There are numerous PRP treatment variables that may be of importance, and the optimal PRP protocol remains unclear. Future investigations should control and analyze the effects of these variables in PRP treatment. High-quality randomized controlled trials are needed to optimize PRP treatment methods and better define the role of PRP in osteoarthritis management in the knee and, potentially, in other joints.
KW - Injections
KW - Knee
KW - Osteoarthritis
KW - Platelet-rich plasma
KW - Regenerative medicine
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U2 - 10.1097/PHM.0000000000000115
DO - 10.1097/PHM.0000000000000115
M3 - Article
C2 - 24879553
AN - SCOPUS:84914818599
VL - 93
SP - S108-S121
JO - American Journal of Physical Medicine
JF - American Journal of Physical Medicine
SN - 0894-9115
IS - 11
ER -