Intima of epineurial arterioles is increased in diabetic polyneuropathy

J. K. Korthals, M. A. Gieron, Peter J Dyck

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Epineurial arteriolar wall components in sural nerve of 45 diabetics (39 with and six without neuropathy) were measured and compared with those of 34 healthy subjects. Intimal area and numbers of intimal nuclei were significantly greater in diabetics than in controls. Regression lines relating intimal to medial area in diabetics and controls had a common slope, but the line for diabetics was at a higher intercept. We found no direct association between increase of intima and severity of nerve fiber degeneration. These studies indicate that intima is increased in arterioles in diabetes, due primarily to proliferation of intimal cells. The increased intima, and possible resulting decrease of nerve perfusion, may contribute to development of diabetic polyneuropathy.

Original languageEnglish (US)
Pages (from-to)1582-1586
Number of pages5
JournalNeurology
Volume38
Issue number10
StatePublished - 1988

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Tunica Intima
Diabetic Neuropathies
Arterioles
Nerve Degeneration
Sural Nerve
Nerve Fibers
Healthy Volunteers
Perfusion
Cell Proliferation

ASJC Scopus subject areas

  • Neuroscience(all)

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Intima of epineurial arterioles is increased in diabetic polyneuropathy. / Korthals, J. K.; Gieron, M. A.; Dyck, Peter J.

In: Neurology, Vol. 38, No. 10, 1988, p. 1582-1586.

Research output: Contribution to journalArticle

Korthals, JK, Gieron, MA & Dyck, PJ 1988, 'Intima of epineurial arterioles is increased in diabetic polyneuropathy', Neurology, vol. 38, no. 10, pp. 1582-1586.
Korthals, J. K. ; Gieron, M. A. ; Dyck, Peter J. / Intima of epineurial arterioles is increased in diabetic polyneuropathy. In: Neurology. 1988 ; Vol. 38, No. 10. pp. 1582-1586.
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