Intestinal pseudo-obstruction and ischemia secondary to both β2-microglobulin and serum A amyloid deposition

A. Borczuk, C. Mannion, Dennis W Dickson, E. Alt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We present the case of a 61-year-old man on long-term hemodialysis in whom early colonic ischemia and pseudo-obstruction were caused by amyloid deposition of both the β2-microglobulin and AA type. The light microscopic diagnosis of amyloidosis was confirmed by Congo red birefringence, immunohistochemistry, and electron microscopy. The two types of amyloid had separate distributions within the colon. While both types affected submucosal and serosal blood vessels, the β2-microglobulin amyloid also formed large masses that displaced smooth muscle cells and was associated with Class II major histocompatibility-positive multinucleated giant cells. The pathogenesis of this uncommon occurrence of two amyloids and the role of chronic inflammation in amyloidogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)577-582
Number of pages6
JournalModern Pathology
Volume8
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

Intestinal Pseudo-Obstruction
Amyloid
Ischemia
Serum
Colonic Pseudo-Obstruction
Birefringence
Congo Red
Histocompatibility
Amyloidosis
Giant Cells
Smooth Muscle Myocytes
Blood Vessels
Renal Dialysis
Electron Microscopy
Colon
Immunohistochemistry
Inflammation
Light

Keywords

  • β-Microglobulin
  • Amyloid
  • Colonic ischemia
  • Pseudo-obstruction
  • Serum A

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Intestinal pseudo-obstruction and ischemia secondary to both β2-microglobulin and serum A amyloid deposition. / Borczuk, A.; Mannion, C.; Dickson, Dennis W; Alt, E.

In: Modern Pathology, Vol. 8, No. 5, 1995, p. 577-582.

Research output: Contribution to journalArticle

@article{da8d77a31fbd45d7af2e5913dfa0f767,
title = "Intestinal pseudo-obstruction and ischemia secondary to both β2-microglobulin and serum A amyloid deposition",
abstract = "We present the case of a 61-year-old man on long-term hemodialysis in whom early colonic ischemia and pseudo-obstruction were caused by amyloid deposition of both the β2-microglobulin and AA type. The light microscopic diagnosis of amyloidosis was confirmed by Congo red birefringence, immunohistochemistry, and electron microscopy. The two types of amyloid had separate distributions within the colon. While both types affected submucosal and serosal blood vessels, the β2-microglobulin amyloid also formed large masses that displaced smooth muscle cells and was associated with Class II major histocompatibility-positive multinucleated giant cells. The pathogenesis of this uncommon occurrence of two amyloids and the role of chronic inflammation in amyloidogenesis are discussed.",
keywords = "β-Microglobulin, Amyloid, Colonic ischemia, Pseudo-obstruction, Serum A",
author = "A. Borczuk and C. Mannion and Dickson, {Dennis W} and E. Alt",
year = "1995",
language = "English (US)",
volume = "8",
pages = "577--582",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Intestinal pseudo-obstruction and ischemia secondary to both β2-microglobulin and serum A amyloid deposition

AU - Borczuk, A.

AU - Mannion, C.

AU - Dickson, Dennis W

AU - Alt, E.

PY - 1995

Y1 - 1995

N2 - We present the case of a 61-year-old man on long-term hemodialysis in whom early colonic ischemia and pseudo-obstruction were caused by amyloid deposition of both the β2-microglobulin and AA type. The light microscopic diagnosis of amyloidosis was confirmed by Congo red birefringence, immunohistochemistry, and electron microscopy. The two types of amyloid had separate distributions within the colon. While both types affected submucosal and serosal blood vessels, the β2-microglobulin amyloid also formed large masses that displaced smooth muscle cells and was associated with Class II major histocompatibility-positive multinucleated giant cells. The pathogenesis of this uncommon occurrence of two amyloids and the role of chronic inflammation in amyloidogenesis are discussed.

AB - We present the case of a 61-year-old man on long-term hemodialysis in whom early colonic ischemia and pseudo-obstruction were caused by amyloid deposition of both the β2-microglobulin and AA type. The light microscopic diagnosis of amyloidosis was confirmed by Congo red birefringence, immunohistochemistry, and electron microscopy. The two types of amyloid had separate distributions within the colon. While both types affected submucosal and serosal blood vessels, the β2-microglobulin amyloid also formed large masses that displaced smooth muscle cells and was associated with Class II major histocompatibility-positive multinucleated giant cells. The pathogenesis of this uncommon occurrence of two amyloids and the role of chronic inflammation in amyloidogenesis are discussed.

KW - β-Microglobulin

KW - Amyloid

KW - Colonic ischemia

KW - Pseudo-obstruction

KW - Serum A

UR - http://www.scopus.com/inward/record.url?scp=0029032546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029032546&partnerID=8YFLogxK

M3 - Article

C2 - 7675780

AN - SCOPUS:0029032546

VL - 8

SP - 577

EP - 582

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 5

ER -