Abstract
Gastrointestinal complications of Waldenstrom macroglobulinemia (WM) are unusual but often treatable. We report a case of WM associated with significant gastrointestinal involvement manifest as chronic diarrhea with protein-losing enteropathy and recurrent venous thromboses. Small bowel biopsy was negative for amyloidosis but revealed intestinal lymphangiectasia with deposition of monoclonal IgM. The patient was treated with cyclophosphamide, vincristine, and prednisone with rapid and complete resolution of the peripheral edema and diarrhea. We follow the case report with a retrospective analysis of patients with WM and gastrointestinal symptoms seen at our institution, and review the available literature on this unusual association. An increased awareness of the gastrointestinal manifestations of WM may help to explain and to treat the chronic, debilitating, and potentially life-threatening symptoms in patients with this lymphoproliferative disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-214 |
| Number of pages | 5 |
| Journal | Medicine |
| Volume | 86 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2007 |
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ASJC Scopus subject areas
- Medicine(all)
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Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. / Pratz, Keith W.; Dingli, David M; Smyrk, Thomas Christopher; Lust, John A.
In: Medicine, Vol. 86, No. 4, 07.2007, p. 210-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia
AU - Pratz, Keith W.
AU - Dingli, David M
AU - Smyrk, Thomas Christopher
AU - Lust, John A.
PY - 2007/7
Y1 - 2007/7
N2 - Gastrointestinal complications of Waldenstrom macroglobulinemia (WM) are unusual but often treatable. We report a case of WM associated with significant gastrointestinal involvement manifest as chronic diarrhea with protein-losing enteropathy and recurrent venous thromboses. Small bowel biopsy was negative for amyloidosis but revealed intestinal lymphangiectasia with deposition of monoclonal IgM. The patient was treated with cyclophosphamide, vincristine, and prednisone with rapid and complete resolution of the peripheral edema and diarrhea. We follow the case report with a retrospective analysis of patients with WM and gastrointestinal symptoms seen at our institution, and review the available literature on this unusual association. An increased awareness of the gastrointestinal manifestations of WM may help to explain and to treat the chronic, debilitating, and potentially life-threatening symptoms in patients with this lymphoproliferative disorder.
AB - Gastrointestinal complications of Waldenstrom macroglobulinemia (WM) are unusual but often treatable. We report a case of WM associated with significant gastrointestinal involvement manifest as chronic diarrhea with protein-losing enteropathy and recurrent venous thromboses. Small bowel biopsy was negative for amyloidosis but revealed intestinal lymphangiectasia with deposition of monoclonal IgM. The patient was treated with cyclophosphamide, vincristine, and prednisone with rapid and complete resolution of the peripheral edema and diarrhea. We follow the case report with a retrospective analysis of patients with WM and gastrointestinal symptoms seen at our institution, and review the available literature on this unusual association. An increased awareness of the gastrointestinal manifestations of WM may help to explain and to treat the chronic, debilitating, and potentially life-threatening symptoms in patients with this lymphoproliferative disorder.
UR - http://www.scopus.com/inward/record.url?scp=34447516904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447516904&partnerID=8YFLogxK
U2 - 10.1097/MD.0b013e31812e5242
DO - 10.1097/MD.0b013e31812e5242
M3 - Article
C2 - 17632262
AN - SCOPUS:34447516904
VL - 86
SP - 210
EP - 214
JO - Medicine (United States)
JF - Medicine (United States)
SN - 1357-3039
IS - 4
ER -