Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia

Keith W. Pratz, David M Dingli, Thomas Christopher Smyrk, John A. Lust

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Gastrointestinal complications of Waldenstrom macroglobulinemia (WM) are unusual but often treatable. We report a case of WM associated with significant gastrointestinal involvement manifest as chronic diarrhea with protein-losing enteropathy and recurrent venous thromboses. Small bowel biopsy was negative for amyloidosis but revealed intestinal lymphangiectasia with deposition of monoclonal IgM. The patient was treated with cyclophosphamide, vincristine, and prednisone with rapid and complete resolution of the peripheral edema and diarrhea. We follow the case report with a retrospective analysis of patients with WM and gastrointestinal symptoms seen at our institution, and review the available literature on this unusual association. An increased awareness of the gastrointestinal manifestations of WM may help to explain and to treat the chronic, debilitating, and potentially life-threatening symptoms in patients with this lymphoproliferative disorder.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalMedicine
Volume86
Issue number4
DOIs
StatePublished - Jul 2007

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Intestinal Lymphangiectasis
Protein-Losing Enteropathies
Waldenstrom Macroglobulinemia
Diarrhea
Lymphoproliferative Disorders
Vincristine
Amyloidosis
Prednisone
Venous Thrombosis
Cyclophosphamide
Immunoglobulin M
Edema
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

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Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. / Pratz, Keith W.; Dingli, David M; Smyrk, Thomas Christopher; Lust, John A.

In: Medicine, Vol. 86, No. 4, 07.2007, p. 210-214.

Research output: Contribution to journalArticle

Pratz, Keith W. ; Dingli, David M ; Smyrk, Thomas Christopher ; Lust, John A. / Intestinal lymphangiectasia with protein-losing enteropathy in Waldenstrom macroglobulinemia. In: Medicine. 2007 ; Vol. 86, No. 4. pp. 210-214.
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