Intestinal control of human postprandial gastric function: The role of components of jejunoileal chyme in regulating gastric secretion and gastric emptying

Laurence J Miller, Juan R. Malagelada, William F. Taylor, Vay Liang W Go

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Intestinal control of gastric secretion and emptying were studied in healthy humans by using intubation-marker-perfusion techniques. An occluding balloon was used to separate the jejunoileal test segment from the more proximal gut. Mixed-nutrient, semielemental meals (300 and 600 calories) were administered while varying the jejunal perfusate: normal saline, jejunal chyme or its protein (casein hydrolysate), lipid (oleic acid), or carbohydrate (maltose) components. The meal in contact with the stomach and duodenum increased gastric secretion above fasting levels. This was partially inhibited by whole chyme in contact with the jejunum, the lipid and carbohydrate components of chyme mediating this inhibition. Jejunoileal chyme inhibited gastric emptying, with all three nutrient components acting as inhibitors. Effects on gastric secretion and emptying were dose-dependent, being greater after the larger meal and most prominent in the early postprandial period; these effects on gastric emptying were more prominent than those on gastric secretion. These results suggest that the intestinal phase of gastric function is directed mainly toward regulation of the reservoir function of the stomach: to adapt the gastric delivery of nutrients and fluid to the capability for efficient digestion and absorption.

Original languageEnglish (US)
Pages (from-to)763-769
Number of pages7
JournalGastroenterology
Volume80
Issue number4
StatePublished - 1981

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Gastric Emptying
Stomach
Meals
Food
Postprandial Period
Carbohydrates
Protein Hydrolysates
Lipids
Maltose
Jejunum
Oleic Acid
Duodenum
Intubation
Digestion
Fasting
Perfusion

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Intestinal control of human postprandial gastric function : The role of components of jejunoileal chyme in regulating gastric secretion and gastric emptying. / Miller, Laurence J; Malagelada, Juan R.; Taylor, William F.; Go, Vay Liang W.

In: Gastroenterology, Vol. 80, No. 4, 1981, p. 763-769.

Research output: Contribution to journalArticle

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