Intestinal cell cycle regulation.

T. C. Ko, W. A. Bresnahan, E Aubrey Thompson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-beta, which is expressed in the gut epithelium.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalProgress in cell cycle research
Volume3
StatePublished - 1997
Externally publishedYes

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Cell Cycle
Cyclin-Dependent Kinases
Cell Cycle Proteins
Cyclins
Intestinal Mucosa
Transforming Growth Factor beta
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Epithelium
Epithelial Cells
Cell Proliferation
Food

Cite this

Intestinal cell cycle regulation. / Ko, T. C.; Bresnahan, W. A.; Thompson, E Aubrey.

In: Progress in cell cycle research, Vol. 3, 1997, p. 43-52.

Research output: Contribution to journalArticle

Ko, T. C. ; Bresnahan, W. A. ; Thompson, E Aubrey. / Intestinal cell cycle regulation. In: Progress in cell cycle research. 1997 ; Vol. 3. pp. 43-52.
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