TY - JOUR
T1 - Intersubject variability and intrasubject reproducibility of the bereitschaftspotential
AU - Evidente, Virgilio Gerald H.
AU - Caviness, John N.
AU - Jamieson, Bonnie
AU - Weaver, Amy
AU - Joshi, Neel
PY - 1999
Y1 - 1999
N2 - We assessed the intersubject variability and intrasubject reproducibility of the bereitschaftspotential (BP). Twenty healthy volunteers performed extensions of their wrist in a self-paced manner every 5-10 seconds. A surface electromyography (EMG) electrode was attached to the wrist extensor group of the dominant hand to record at least 100 wrist movements, and electroencephalography electrodes were placed over the scalp. Trials were performed at baseline, 15 minutes, 4 hours, and 4 weeks. Measures derived from the BP included area 1 (-2000 to -650 msec), area 2 (-650-0 msec), total area (area 1 + area 2), amplitude at -650 msec, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec (trigger). Our findings revealed different variability/reproducibility depending on the particular BP measure being analyzed. Using intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC) as measures of intrasubject reproducibility, area 2, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec produced the best values. We conclude that in studies that attempt to quantify BP changes before and after an intervention in the same group of subjects, the most reproducible BP measures are those pertaining to the late BP component.
AB - We assessed the intersubject variability and intrasubject reproducibility of the bereitschaftspotential (BP). Twenty healthy volunteers performed extensions of their wrist in a self-paced manner every 5-10 seconds. A surface electromyography (EMG) electrode was attached to the wrist extensor group of the dominant hand to record at least 100 wrist movements, and electroencephalography electrodes were placed over the scalp. Trials were performed at baseline, 15 minutes, 4 hours, and 4 weeks. Measures derived from the BP included area 1 (-2000 to -650 msec), area 2 (-650-0 msec), total area (area 1 + area 2), amplitude at -650 msec, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec (trigger). Our findings revealed different variability/reproducibility depending on the particular BP measure being analyzed. Using intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC) as measures of intrasubject reproducibility, area 2, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec produced the best values. We conclude that in studies that attempt to quantify BP changes before and after an intervention in the same group of subjects, the most reproducible BP measures are those pertaining to the late BP component.
KW - Back-averaging
KW - Bereitschaftspotential
KW - EEG
UR - http://www.scopus.com/inward/record.url?scp=0033462178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033462178&partnerID=8YFLogxK
U2 - 10.1002/1531-8257(199903)14:2<313::AID-MDS1017>3.0.CO;2-1
DO - 10.1002/1531-8257(199903)14:2<313::AID-MDS1017>3.0.CO;2-1
M3 - Article
C2 - 10091626
AN - SCOPUS:0033462178
SN - 0885-3185
VL - 14
SP - 313
EP - 319
JO - Movement Disorders
JF - Movement Disorders
IS - 2
ER -