Intersubject variability and intrasubject reproducibility of the bereitschaftspotential

Virgilio Gerald H Evidente, John Nathaniel Caviness, Bonnie Jamieson, Amy Weaver, Neel Joshi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We assessed the intersubject variability and intrasubject reproducibility of the bereitschaftspotential (BP). Twenty healthy volunteers performed extensions of their wrist in a self-paced manner every 5-10 seconds. A surface electromyography (EMG) electrode was attached to the wrist extensor group of the dominant hand to record at least 100 wrist movements, and electroencephalography electrodes were placed over the scalp. Trials were performed at baseline, 15 minutes, 4 hours, and 4 weeks. Measures derived from the BP included area 1 (-2000 to -650 msec), area 2 (-650-0 msec), total area (area 1 + area 2), amplitude at -650 msec, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec (trigger). Our findings revealed different variability/reproducibility depending on the particular BP measure being analyzed. Using intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC) as measures of intrasubject reproducibility, area 2, amplitude at peak negativity prior to EMG onset, and amplitude at 0 msec produced the best values. We conclude that in studies that attempt to quantify BP changes before and after an intervention in the same group of subjects, the most reproducible BP measures are those pertaining to the late BP component.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalMovement Disorders
Volume14
Issue number2
DOIs
StatePublished - 1999

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Contingent Negative Variation
Electromyography
Wrist
Electrodes
Scalp
Electroencephalography
Healthy Volunteers
Hand

Keywords

  • Back-averaging
  • Bereitschaftspotential
  • EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intersubject variability and intrasubject reproducibility of the bereitschaftspotential. / Evidente, Virgilio Gerald H; Caviness, John Nathaniel; Jamieson, Bonnie; Weaver, Amy; Joshi, Neel.

In: Movement Disorders, Vol. 14, No. 2, 1999, p. 313-319.

Research output: Contribution to journalArticle

Evidente, Virgilio Gerald H ; Caviness, John Nathaniel ; Jamieson, Bonnie ; Weaver, Amy ; Joshi, Neel. / Intersubject variability and intrasubject reproducibility of the bereitschaftspotential. In: Movement Disorders. 1999 ; Vol. 14, No. 2. pp. 313-319.
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