Interstitial temperature mapping during Prolieve transurethral microwave treatment: Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra

Benjamin T. Larson, David W. Robertson, Christian Huidobro, Cristian Acevedo, David Busel, Joseph Collins, Thayne R. Larson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: Temperature mapping of the prostate during transurethral microwave thermotherapy and imaging of the resultant zones of tissue necrosis have been previously performed using several commercial systems. This study was performed using the Prolieve Thermodilatation System, which simultaneously compresses the prostate with a 46F balloon circulating heated fluid and delivering microwave energy into the prostate. Methods: Interstitial temperature mapping during Prolieve treatment was performed on 10 patients with benign prostatic hyperplasia using 24 temperature sensors arrayed throughout the prostate. Voiding cystourethrograms were performed on 3 additional patients treated without temperature mapping to document the patency of the prostatic urethra 1 hour after treatment. Gadolinium-enhanced magnetic resonance imaging studies were performed on all patients 1 week after treatment to determine the extent and pattern of tissue necrosis resulting from transurethral microwave thermotherapy. Results: Interstitial temperature mapping found that the heating pattern generated by the Prolieve system created average peak temperatures of 51.8°C an average of 7 mm away from the prostatic urethra. These temperatures were greater near the bladder neck and mid-gland than toward the prostatic apex. Subtherapeutic temperatures were seen adjacent to the urethra, consistent with the viable tissue seen on gadolinium-enhanced magnetic resonance imaging sequences. Magnetic resonance imaging also revealed necrotic zones that were consistent with sustained temperatures greater than 45°C. Voiding cystourethrograms showed widely patent prostatic urethras 1 hour after treatment. Conclusions: Transurethral microwave thermotherapy with the Prolieve Thermodilatation System produced sustained therapeutic temperatures that resulted in tissue necrosis while maintaining viable tissue surrounding a temporarily dilated prostatic urethra.

Original languageEnglish (US)
Pages (from-to)1206-1210
Number of pages5
JournalUrology
Volume68
Issue number6
DOIs
StatePublished - Dec 2006

Fingerprint

Induced Hyperthermia
Urethra
Microwaves
Necrosis
Transurethral Resection of Prostate
Temperature
Prostate
Magnetic Resonance Imaging
Gadolinium
Therapeutics
Prostatic Hyperplasia
Heating
Urinary Bladder

ASJC Scopus subject areas

  • Urology

Cite this

Interstitial temperature mapping during Prolieve transurethral microwave treatment : Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra. / Larson, Benjamin T.; Robertson, David W.; Huidobro, Christian; Acevedo, Cristian; Busel, David; Collins, Joseph; Larson, Thayne R.

In: Urology, Vol. 68, No. 6, 12.2006, p. 1206-1210.

Research output: Contribution to journalArticle

Larson, Benjamin T. ; Robertson, David W. ; Huidobro, Christian ; Acevedo, Cristian ; Busel, David ; Collins, Joseph ; Larson, Thayne R. / Interstitial temperature mapping during Prolieve transurethral microwave treatment : Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra. In: Urology. 2006 ; Vol. 68, No. 6. pp. 1206-1210.
@article{170632af00b94f9ca8e38d54f00e9406,
title = "Interstitial temperature mapping during Prolieve transurethral microwave treatment: Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra",
abstract = "Objectives: Temperature mapping of the prostate during transurethral microwave thermotherapy and imaging of the resultant zones of tissue necrosis have been previously performed using several commercial systems. This study was performed using the Prolieve Thermodilatation System, which simultaneously compresses the prostate with a 46F balloon circulating heated fluid and delivering microwave energy into the prostate. Methods: Interstitial temperature mapping during Prolieve treatment was performed on 10 patients with benign prostatic hyperplasia using 24 temperature sensors arrayed throughout the prostate. Voiding cystourethrograms were performed on 3 additional patients treated without temperature mapping to document the patency of the prostatic urethra 1 hour after treatment. Gadolinium-enhanced magnetic resonance imaging studies were performed on all patients 1 week after treatment to determine the extent and pattern of tissue necrosis resulting from transurethral microwave thermotherapy. Results: Interstitial temperature mapping found that the heating pattern generated by the Prolieve system created average peak temperatures of 51.8°C an average of 7 mm away from the prostatic urethra. These temperatures were greater near the bladder neck and mid-gland than toward the prostatic apex. Subtherapeutic temperatures were seen adjacent to the urethra, consistent with the viable tissue seen on gadolinium-enhanced magnetic resonance imaging sequences. Magnetic resonance imaging also revealed necrotic zones that were consistent with sustained temperatures greater than 45°C. Voiding cystourethrograms showed widely patent prostatic urethras 1 hour after treatment. Conclusions: Transurethral microwave thermotherapy with the Prolieve Thermodilatation System produced sustained therapeutic temperatures that resulted in tissue necrosis while maintaining viable tissue surrounding a temporarily dilated prostatic urethra.",
author = "Larson, {Benjamin T.} and Robertson, {David W.} and Christian Huidobro and Cristian Acevedo and David Busel and Joseph Collins and Larson, {Thayne R.}",
year = "2006",
month = "12",
doi = "10.1016/j.urology.2006.09.006",
language = "English (US)",
volume = "68",
pages = "1206--1210",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Interstitial temperature mapping during Prolieve transurethral microwave treatment

T2 - Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra

AU - Larson, Benjamin T.

AU - Robertson, David W.

AU - Huidobro, Christian

AU - Acevedo, Cristian

AU - Busel, David

AU - Collins, Joseph

AU - Larson, Thayne R.

PY - 2006/12

Y1 - 2006/12

N2 - Objectives: Temperature mapping of the prostate during transurethral microwave thermotherapy and imaging of the resultant zones of tissue necrosis have been previously performed using several commercial systems. This study was performed using the Prolieve Thermodilatation System, which simultaneously compresses the prostate with a 46F balloon circulating heated fluid and delivering microwave energy into the prostate. Methods: Interstitial temperature mapping during Prolieve treatment was performed on 10 patients with benign prostatic hyperplasia using 24 temperature sensors arrayed throughout the prostate. Voiding cystourethrograms were performed on 3 additional patients treated without temperature mapping to document the patency of the prostatic urethra 1 hour after treatment. Gadolinium-enhanced magnetic resonance imaging studies were performed on all patients 1 week after treatment to determine the extent and pattern of tissue necrosis resulting from transurethral microwave thermotherapy. Results: Interstitial temperature mapping found that the heating pattern generated by the Prolieve system created average peak temperatures of 51.8°C an average of 7 mm away from the prostatic urethra. These temperatures were greater near the bladder neck and mid-gland than toward the prostatic apex. Subtherapeutic temperatures were seen adjacent to the urethra, consistent with the viable tissue seen on gadolinium-enhanced magnetic resonance imaging sequences. Magnetic resonance imaging also revealed necrotic zones that were consistent with sustained temperatures greater than 45°C. Voiding cystourethrograms showed widely patent prostatic urethras 1 hour after treatment. Conclusions: Transurethral microwave thermotherapy with the Prolieve Thermodilatation System produced sustained therapeutic temperatures that resulted in tissue necrosis while maintaining viable tissue surrounding a temporarily dilated prostatic urethra.

AB - Objectives: Temperature mapping of the prostate during transurethral microwave thermotherapy and imaging of the resultant zones of tissue necrosis have been previously performed using several commercial systems. This study was performed using the Prolieve Thermodilatation System, which simultaneously compresses the prostate with a 46F balloon circulating heated fluid and delivering microwave energy into the prostate. Methods: Interstitial temperature mapping during Prolieve treatment was performed on 10 patients with benign prostatic hyperplasia using 24 temperature sensors arrayed throughout the prostate. Voiding cystourethrograms were performed on 3 additional patients treated without temperature mapping to document the patency of the prostatic urethra 1 hour after treatment. Gadolinium-enhanced magnetic resonance imaging studies were performed on all patients 1 week after treatment to determine the extent and pattern of tissue necrosis resulting from transurethral microwave thermotherapy. Results: Interstitial temperature mapping found that the heating pattern generated by the Prolieve system created average peak temperatures of 51.8°C an average of 7 mm away from the prostatic urethra. These temperatures were greater near the bladder neck and mid-gland than toward the prostatic apex. Subtherapeutic temperatures were seen adjacent to the urethra, consistent with the viable tissue seen on gadolinium-enhanced magnetic resonance imaging sequences. Magnetic resonance imaging also revealed necrotic zones that were consistent with sustained temperatures greater than 45°C. Voiding cystourethrograms showed widely patent prostatic urethras 1 hour after treatment. Conclusions: Transurethral microwave thermotherapy with the Prolieve Thermodilatation System produced sustained therapeutic temperatures that resulted in tissue necrosis while maintaining viable tissue surrounding a temporarily dilated prostatic urethra.

UR - http://www.scopus.com/inward/record.url?scp=33845462131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845462131&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2006.09.006

DO - 10.1016/j.urology.2006.09.006

M3 - Article

C2 - 17141828

AN - SCOPUS:33845462131

VL - 68

SP - 1206

EP - 1210

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -