Interstitial temperature mapping during Prolieve transurethral microwave treatment: Imaging reveals thermotherapy temperatures resulting in tissue necrosis and patent prostatic urethra

Benjamin T. Larson, David W. Robertson, Christian Huidobro, Cristian Acevedo, David Busel, Joseph Collins, Thayne R. Larson

Research output: Contribution to journalArticle

3 Scopus citations


Objectives: Temperature mapping of the prostate during transurethral microwave thermotherapy and imaging of the resultant zones of tissue necrosis have been previously performed using several commercial systems. This study was performed using the Prolieve Thermodilatation System, which simultaneously compresses the prostate with a 46F balloon circulating heated fluid and delivering microwave energy into the prostate. Methods: Interstitial temperature mapping during Prolieve treatment was performed on 10 patients with benign prostatic hyperplasia using 24 temperature sensors arrayed throughout the prostate. Voiding cystourethrograms were performed on 3 additional patients treated without temperature mapping to document the patency of the prostatic urethra 1 hour after treatment. Gadolinium-enhanced magnetic resonance imaging studies were performed on all patients 1 week after treatment to determine the extent and pattern of tissue necrosis resulting from transurethral microwave thermotherapy. Results: Interstitial temperature mapping found that the heating pattern generated by the Prolieve system created average peak temperatures of 51.8°C an average of 7 mm away from the prostatic urethra. These temperatures were greater near the bladder neck and mid-gland than toward the prostatic apex. Subtherapeutic temperatures were seen adjacent to the urethra, consistent with the viable tissue seen on gadolinium-enhanced magnetic resonance imaging sequences. Magnetic resonance imaging also revealed necrotic zones that were consistent with sustained temperatures greater than 45°C. Voiding cystourethrograms showed widely patent prostatic urethras 1 hour after treatment. Conclusions: Transurethral microwave thermotherapy with the Prolieve Thermodilatation System produced sustained therapeutic temperatures that resulted in tissue necrosis while maintaining viable tissue surrounding a temporarily dilated prostatic urethra.

Original languageEnglish (US)
Pages (from-to)1206-1210
Number of pages5
Issue number6
StatePublished - Dec 1 2006


ASJC Scopus subject areas

  • Urology

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