TY - JOUR
T1 - Interstitial lung disease in rheumatoid arthritis
AU - Phillips, Kristine
AU - Flaherty, Kevin R.
AU - Matteson, Eric L.
AU - Bongartz, Tim
AU - Bathon, Joan
AU - Brown, Kevin K.
AU - Dellaripa, Paul F.
PY - 2010
Y1 - 2010
N2 - Rheumatoid arthritis (RA) affects 1-2% of the general population. Although often thought of as primarily a localized inflammatory disorder with associated joint destruction, it is a diffuse systemic disease. Extra-articular manifestations of rheumatoid arthritis can be demonstrated in almost 50% of patients with RA, and include pulmonary, cardiac, ocular, renal, hematologic, and neurologic involvement. In this article, we review recent studies of interstitial lung disease (ILD) in RA with a focus on clinical and pathological features of rheumatoid arthritis associated interstitial lung disease (RA-ILD). We discuss an approach to the diagnosis and treatment of RA-ILD including potential biomarkers, and conclude by outlining areas for future research.
AB - Rheumatoid arthritis (RA) affects 1-2% of the general population. Although often thought of as primarily a localized inflammatory disorder with associated joint destruction, it is a diffuse systemic disease. Extra-articular manifestations of rheumatoid arthritis can be demonstrated in almost 50% of patients with RA, and include pulmonary, cardiac, ocular, renal, hematologic, and neurologic involvement. In this article, we review recent studies of interstitial lung disease (ILD) in RA with a focus on clinical and pathological features of rheumatoid arthritis associated interstitial lung disease (RA-ILD). We discuss an approach to the diagnosis and treatment of RA-ILD including potential biomarkers, and conclude by outlining areas for future research.
KW - Interstitial lung disease
KW - Pulmonary fibrosis
KW - Rheumatoid arthritis
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U2 - 10.2174/157339710791330696
DO - 10.2174/157339710791330696
M3 - Article
AN - SCOPUS:77956578646
SN - 1573-3971
VL - 6
SP - 120
EP - 126
JO - Current Rheumatology Reviews
JF - Current Rheumatology Reviews
IS - 2
ER -