Interstitial lung disease in polymyositis and dermatomyositis. Clinical features and prognosis as correlated with histologic findings

H. D. Tazelaar, R. W. Viggiano, J. Pickersgill, T. V. Colby

Research output: Contribution to journalArticle

339 Citations (Scopus)

Abstract

Open lung biopsies from 14 patients and autopsy tissue from one patient with polymyositis/dermatomyositis were reviewed in an attempt to correlate histologic features with clinical, radiographic, and prognostic variables. Three major groups based on histologic patterns were identified: bronchiolitis obliterans organizing pneumonia (BOOP), usual interstitial pneumonia (UIP), and diffuse alveolar damage (DAD). Patients with BOOP had a more favorable prognosis than did patients with UIP. Patients with DAD had a uniformly poor prognosis. One patient had a cellular interstitial pneumonia and did well. Histologic subclassification of the interstitial lung disease proved to be a better predictor of survival than did the radiographic appearance or the clinical presentation. These findings suggest that there is a broader range of histologic findings in polymyositis-dermatomyositis than is suggested in the literature and that subclassification may be useful for prognosis.

Original languageEnglish (US)
Pages (from-to)727-733
Number of pages7
JournalAmerican Review of Respiratory Disease
Volume141
Issue number3 I
StatePublished - 1990

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Dermatomyositis
Interstitial Lung Diseases
Cryptogenic Organizing Pneumonia
Idiopathic Pulmonary Fibrosis
Autopsy
Biopsy
Lung
Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Interstitial lung disease in polymyositis and dermatomyositis. Clinical features and prognosis as correlated with histologic findings. / Tazelaar, H. D.; Viggiano, R. W.; Pickersgill, J.; Colby, T. V.

In: American Review of Respiratory Disease, Vol. 141, No. 3 I, 1990, p. 727-733.

Research output: Contribution to journalArticle

Tazelaar, H. D. ; Viggiano, R. W. ; Pickersgill, J. ; Colby, T. V. / Interstitial lung disease in polymyositis and dermatomyositis. Clinical features and prognosis as correlated with histologic findings. In: American Review of Respiratory Disease. 1990 ; Vol. 141, No. 3 I. pp. 727-733.
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