Interstitial cells of Cajal in diabetic gastroenteropathy

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Gastroenteropathy causes considerable morbidity in patients with diabetes mellitus and represents a major healthcare burden. Current treatments are largely symptomatic and frequently ineffective. Development of new therapeutic options is hampered by poor understanding of the underlying pathomechanisms. Experimental studies and sparse human data indicate that diabetic gastroenteropathy is multifactorial and involves not only parasympathetic and sympathetic autonomic nerves, but also enteric neurons, smooth muscle cells and interstitial cells of Cajal (ICC). ICC are mesenchymal cells that occur throughout the muscular coat of the gastrointestinal tract and provide functions critical for normal gastrointestinal motility including generation and propagation of electrical slow waves and mediation of bidirectional communication between the autonomic nervous system and smooth muscle cells. Through these functions, and in concert with other cell types of the gastrointestinal muscles, ICC support basic gastrointestinal functions such as digestion, absorption and waste removal. Loss or dysfunction of ICC in various dysmotilities and their animal models has been shown to lead to gastric dysrhythmias, gastroparesis, slow intestinal transit, impaired neuroeffector mechanisms and altered visceral afferent signalling that are considered hallmarks of diabetic gastroenteropathy. These findings and an increasing body of evidence indicating disruptions of ICC networks in diabetes suggest that the loss of ICC in this disorder is probably of functional significance and could even be a major pathogenetic factor. Future research should focus on the identification of the molecular and cellular mechanisms underlying ICC loss in diabetes and the translation of the experimental findings into treatments.

Original languageEnglish (US)
Pages (from-to)8-18
Number of pages11
JournalNeurogastroenterology and Motility
Volume20
Issue number1
DOIs
StatePublished - Jan 2008

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Interstitial Cells of Cajal
Smooth Muscle Myocytes
Visceral Afferents
Gastroparesis
Autonomic Pathways
Gastrointestinal Motility
Autonomic Nervous System
Muscle Cells
Gastrointestinal Tract
Digestion
Stomach
Diabetes Mellitus
Therapeutics
Animal Models
Communication
Morbidity
Delivery of Health Care
Neurons

Keywords

  • Dysmotility
  • Dysrhythmia
  • Hyperglycaemia
  • Myopathy
  • Neuromuscular neurotransmission
  • Neuropathy

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Interstitial cells of Cajal in diabetic gastroenteropathy. / Ordog, Tamas.

In: Neurogastroenterology and Motility, Vol. 20, No. 1, 01.2008, p. 8-18.

Research output: Contribution to journalArticle

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