Interpreting diagnostic tests with continuous results and no gold standard: A common scenario explained using the tuberculin skin test

Claudia C. Dobler, Mohammad H Murad

Research output: Contribution to journalArticle

2 Scopus citations


Practitioners of evidence-based medicine commonly encounter diagnostic tests with continuous results and no gold standard. In contrast, the traditional critical appraisal teachings assume a binary test (2×2 table) with a gold standard. In this guide, we use the example of the tuberculin skin test to illustrate a simple approach facilitated by using stratum-specific likelihood ratios and odds of developing future patient-important events. This approach can aid practitioners in the interpretation and application of diagnostic tests to patient care.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalEvidence-Based Medicine
Issue number6
StatePublished - Dec 1 2017



  • epidemiology
  • general medicine (see internal medicine)
  • tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

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