Interpretation of cytogenetic results in multiple myeloma for clinical practice

A. M. Rajan, S Vincent Rajkumar

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by the number and complexity of the abnormalities, the methods used to detect them and the disease stage at which they are detected. Specific cytogenetic abnormalities affect clinical presentation, progression of smoldering multiple myeloma (SMM) to MM, prognosis of MM and management strategies. The goal of this paper is to provide a review of how MM is classified into specific subtypes based on primary cytogenetic abnormalities and to provide a concise overview of how to interpret cytogenetic abnormalities based on the disease stage to aid clinical practice and patient management.

Original languageEnglish (US)
Article numbere365
JournalBlood Cancer Journal
Volume5
Issue number10
DOIs
StatePublished - Oct 30 2015

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ASJC Scopus subject areas

  • Hematology
  • Oncology

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