Interplay of estrogen receptors and FOXA factors in the liver cancer

Yongbing Zhao; Zhaoyu Li

doi:10.1016/j.mce.2015.01.043

Interplay of estrogen receptors and FOXA factors in the liver cancer

Yongbing Zhao, Zhaoyu Li

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Liver cancer is the fifth most common cancer in human with male dominance. Sexual dimorphism of liver cancer is conserved from rodents to humans, which was firstly found in mice in late 1930s and female mice were resistant to liver cancer. Sex hormones were found to affect the incidence of liver cancer in rodents. Estrogen receptor alpha (ERα)-mediated estrogen signaling or androgen receptor-mediated androgen signaling prevents or promotes the growth of rodent liver tumors, respectively. Forkhead box protein A (Foxa) factors, Foxa1 and Foxa2, also known as pioneer transcription factors in liver specification, are essential for both estrogen and androgen signaling by acting as central regulators of sexual dimorphism in liver cancer. This review mainly focuses on the interplay between ERα and FOXA factors in liver cancer, and summarizes recent breakthrough studies in elucidating the mechanisms of sexual dimorphism in liver cancer.

Original language	English (US)
Pages (from-to)	334-339
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	418
DOIs	https://doi.org/10.1016/j.mce.2015.01.043
State	Published - Dec 15 2015

Keywords

Estrogen receptor (ER)
FOXA1
FOXA2
Hepatocellular carcinoma (HCC)
Liver cancer
Sexual dimorphism

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2015.01.043

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title = "Interplay of estrogen receptors and FOXA factors in the liver cancer",

abstract = "Liver cancer is the fifth most common cancer in human with male dominance. Sexual dimorphism of liver cancer is conserved from rodents to humans, which was firstly found in mice in late 1930s and female mice were resistant to liver cancer. Sex hormones were found to affect the incidence of liver cancer in rodents. Estrogen receptor alpha (ERα)-mediated estrogen signaling or androgen receptor-mediated androgen signaling prevents or promotes the growth of rodent liver tumors, respectively. Forkhead box protein A (Foxa) factors, Foxa1 and Foxa2, also known as pioneer transcription factors in liver specification, are essential for both estrogen and androgen signaling by acting as central regulators of sexual dimorphism in liver cancer. This review mainly focuses on the interplay between ERα and FOXA factors in liver cancer, and summarizes recent breakthrough studies in elucidating the mechanisms of sexual dimorphism in liver cancer.",

keywords = "Estrogen receptor (ER), FOXA1, FOXA2, Hepatocellular carcinoma (HCC), Liver cancer, Sexual dimorphism",

author = "Yongbing Zhao and Zhaoyu Li",

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year = "2015",

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doi = "10.1016/j.mce.2015.01.043",

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AU - Zhao, Yongbing

AU - Li, Zhaoyu

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AB - Liver cancer is the fifth most common cancer in human with male dominance. Sexual dimorphism of liver cancer is conserved from rodents to humans, which was firstly found in mice in late 1930s and female mice were resistant to liver cancer. Sex hormones were found to affect the incidence of liver cancer in rodents. Estrogen receptor alpha (ERα)-mediated estrogen signaling or androgen receptor-mediated androgen signaling prevents or promotes the growth of rodent liver tumors, respectively. Forkhead box protein A (Foxa) factors, Foxa1 and Foxa2, also known as pioneer transcription factors in liver specification, are essential for both estrogen and androgen signaling by acting as central regulators of sexual dimorphism in liver cancer. This review mainly focuses on the interplay between ERα and FOXA factors in liver cancer, and summarizes recent breakthrough studies in elucidating the mechanisms of sexual dimorphism in liver cancer.

KW - Estrogen receptor (ER)

KW - FOXA1

KW - FOXA2

KW - Hepatocellular carcinoma (HCC)

KW - Liver cancer

KW - Sexual dimorphism

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Interplay of estrogen receptors and FOXA factors in the liver cancer

Abstract

Keywords

ASJC Scopus subject areas

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