Interplatform reproducibility of liver and spleen stiffness measured with MR elastography

Temel Kaya Yasar, Mathilde Wagner, Octavia Bane, Cecilia Besa, James S. Babb, Stephan Kannengiesser, Maggie Fung, Richard Lorne Ehman, Bachir Taouli

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Purpose: To assess interplatform reproducibility of liver stiffness (LS) and spleen stiffness (SS) measured with magnetic resonance elastography (MRE) based on a 2D gradient echo (GRE) sequence. Materials and Methods: This prospective Health Insurance Portability and Accountability Act (HIPAA)-compliant and Institutional Review Board (IRB)-approved study involved 12 subjects (five healthy volunteers and seven patients with liver disease). A multislice 2D-GRE-based MRE sequence was performed using two systems from different vendors (3.0T GE and 1.5T Siemens) on the same day. Two independent observers measured LS and SS on confidence maps. Bland-Altman analysis (with coefficient of reproducibility, CR), coefficient of variability (CV), and intraclass correlation (ICC) were used to analyze interplatform, intra- and interobserver variability. Human data were validated using a gelatin-based phantom. Results: There was excellent reproducibility of phantom stiffness measurement (CV 4.4%). Mean LS values were 3.44-3.48 kPa and 3.62-3.63 kPa, and mean SS values were 7.54-7.91 kPa and 8.40-8.85 kPa at 3.0T and 1.5T for observers 1 and 2, respectively. The mean CVs between platforms were 9.2%-11.5% and 13.1%-14.4% for LS and SS, respectively, for observers 1 and 2. There was excellent interplatform reproducibility (ICC >0.88 and CR 0.99, CV 0.97, CV and CR

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2015

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Keywords

  • Interplatform MRE
  • Liver stiffness
  • Magnetic resonance elastography
  • Spleen stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Yasar, T. K., Wagner, M., Bane, O., Besa, C., Babb, J. S., Kannengiesser, S., Fung, M., Ehman, R. L., & Taouli, B. (Accepted/In press). Interplatform reproducibility of liver and spleen stiffness measured with MR elastography. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.25077