Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma

Fausto J. Rodriguez, Renan A. Mota, Bernd W. Scheithauer, Caterina Giannini, Hilary Blair, Kent C. New, Kevin J. Wu, Dennis W Dickson, Robert Brian Jenkins

Research output: Contribution to journalArticle

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Abstract

Co-deletion of chromosome arms 1p and 19q, characteristic of oligodendroglial tumors, was recently found to be mediated by t(1;19)(q10;p10). To evaluate the prevalence of 1p19q co-deletion and t(1;19) in extraventricular neurocytomas (EVN), we studied tumors from 23 patients, including 13 females and 10 males (median age at diagnosis 34 years, range 2-76 years). Fluorescence in situ hybridization (FISH) studies were performed with probes targeting 1p36/1q25 and 19q13/19p13 to assess for 1p19q co-deletion, as well as chromosome 1 α-satellite and 19p12 to detect t(1;19)(q10;p10). FISH was successful in 21 (91%) cases and demonstrated 1p19q co-deletion in five cases (24%) or isolated 1p loss in two cases (10%). Evidence for t(1;19) was found in four (of five) cases with 1p19q co-deletion. Three tumors with 1p19q loss and t(1;19) demonstrated atypical histologic features, compared with one (of 17) tumors without 1p19q co-deletion (P = 0.01, Fisher exact test). In addition, tumors with t(1;19) showed increased mitotic activity compared with tumors without t(1;19) (P = 0.045; Wilcoxon rank sum test). The four patients with t(1;19) developed tumor recurrence (n = 3), or expired (n = 2) 3.5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors.

Original languageEnglish (US)
Pages (from-to)623-629
Number of pages7
JournalBrain Pathology
Volume19
Issue number4
DOIs
StatePublished - Oct 2009

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Neurocytoma
Interphase
Cytogenetics
Neoplasms
Nonparametric Statistics
Fluorescence In Situ Hybridization
Chromosome Deletion
Chromosomes, Human, Pair 1
Histology
Recurrence

Keywords

  • 1p19q
  • FISH
  • Neurocytoma
  • Oligodendroglioma
  • T(1;19)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma. / Rodriguez, Fausto J.; Mota, Renan A.; Scheithauer, Bernd W.; Giannini, Caterina; Blair, Hilary; New, Kent C.; Wu, Kevin J.; Dickson, Dennis W; Jenkins, Robert Brian.

In: Brain Pathology, Vol. 19, No. 4, 10.2009, p. 623-629.

Research output: Contribution to journalArticle

Rodriguez, Fausto J. ; Mota, Renan A. ; Scheithauer, Bernd W. ; Giannini, Caterina ; Blair, Hilary ; New, Kent C. ; Wu, Kevin J. ; Dickson, Dennis W ; Jenkins, Robert Brian. / Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma. In: Brain Pathology. 2009 ; Vol. 19, No. 4. pp. 623-629.
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abstract = "Co-deletion of chromosome arms 1p and 19q, characteristic of oligodendroglial tumors, was recently found to be mediated by t(1;19)(q10;p10). To evaluate the prevalence of 1p19q co-deletion and t(1;19) in extraventricular neurocytomas (EVN), we studied tumors from 23 patients, including 13 females and 10 males (median age at diagnosis 34 years, range 2-76 years). Fluorescence in situ hybridization (FISH) studies were performed with probes targeting 1p36/1q25 and 19q13/19p13 to assess for 1p19q co-deletion, as well as chromosome 1 α-satellite and 19p12 to detect t(1;19)(q10;p10). FISH was successful in 21 (91{\%}) cases and demonstrated 1p19q co-deletion in five cases (24{\%}) or isolated 1p loss in two cases (10{\%}). Evidence for t(1;19) was found in four (of five) cases with 1p19q co-deletion. Three tumors with 1p19q loss and t(1;19) demonstrated atypical histologic features, compared with one (of 17) tumors without 1p19q co-deletion (P = 0.01, Fisher exact test). In addition, tumors with t(1;19) showed increased mitotic activity compared with tumors without t(1;19) (P = 0.045; Wilcoxon rank sum test). The four patients with t(1;19) developed tumor recurrence (n = 3), or expired (n = 2) 3.5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors.",
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AU - Mota, Renan A.

AU - Scheithauer, Bernd W.

AU - Giannini, Caterina

AU - Blair, Hilary

AU - New, Kent C.

AU - Wu, Kevin J.

AU - Dickson, Dennis W

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