International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the Mammalian TRP ion channel family

Long Jun Wu, Tara Beth Sweet, David E. Clapham

Research output: Contribution to journalReview article

346 Scopus citations

Abstract

Transient receptor potential (TRP) channels are a large family of ion channel proteins, surpassed in number in mammals only by voltage-gated potassium channels. TRP channels are activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. They respond to environmental stimuli such as temperature, pH, osmolarity, pheromones, taste, and plant compounds, and intracellular stimuli such as Ca2+ and phosphatidylinositol signal transduction pathways. However, it is still largely unknown how TRP channels are activated in vivo. Despite the uncertainties, emerging evidence using TRP channel knockout mice indicates that these channels have broad function in physiology. Here we review the recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels.

Original languageEnglish (US)
Pages (from-to)381-404
Number of pages24
JournalPharmacological Reviews
Volume62
Issue number3
DOIs
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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