International uniform response criteria for multiple myeloma

B. G.M. Durie; J. L. Harousseau; J. S. Miguel; J. Bladé; B. Barlogie; K. Anderson; M. Gertz; M. Dimopoulos; J. Westin; P. Sonneveld; H. Ludwig; G. Gahrton; M. Beksac; J. Crowley; A. Belch; M. Boccadaro; M. Cavo; I. Turesson; D. Joshua; D. Vesole; R. Kyle; G. Tricot; R. Alexanian; M. Attal; G. Merlini; R. Powles; P. Richardson; K. Shimizu; P. Tosi; S. V. Rajkumar; G. Morgan

doi:10.1038/sj.leu.2404284

International uniform response criteria for multiple myeloma

B. G.M. Durie, J. L. Harousseau, J. S. Miguel, J. Bladé, B. Barlogie, K. Anderson, M. Gertz, M. Dimopoulos, J. Westin, P. Sonneveld, H. Ludwig, G. Gahrton, M. Beksac, J. Crowley, A. Belch, M. Boccadaro, M. Cavo, I. Turesson, D. Joshua, D. VesoleR. Kyle, G. Tricot, R. Alexanian, M. Attal, G. Merlini, R. Powles, P. Richardson, K. Shimizu, P. Tosi, S. V. Rajkumar, G. Morgan

Hematology

Research output: Contribution to journal › Article › peer-review

2037 Scopus citations

Abstract

New uniform response criteria are required to adequately assess clinicaloutcomes in myeloma. The European Group for Blood and Bone MarrowTransplant/International Bone Marrow Transplant Registry criteria have beenexpanded, clarified and updated to provide a new comprehensive evaluationsystem. Categories for stringent complete response and very good partialresponse are added. The serum free light-chain assay is included to allowevaluation of patients with oligo-secretory disease. Inconsistencies in priorcriteria are clarified making confirmation of response and disease progressioneasier to perform. Emphasis is placed upon time to event and duration ofresponse as critical end points. The requirements necessary to use overallsurvival duration as the ultimate end point are discussed. It is anticipatedthat the International Response Criteria for multiple myeloma will be widelyused in future clinical trials of myeloma.

Original language	English (US)
Pages (from-to)	1467-1473
Number of pages	7
Journal	Leukemia
Volume	20
Issue number	9
DOIs	https://doi.org/10.1038/sj.leu.2404284
State	Published - Sep 1 2006

Keywords

Clinical outcomes
Myeloma
Response criteria
Staging
Survival duration
Uniform criteria

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/sj.leu.2404284

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Durie, B. G. M., Harousseau, J. L., Miguel, J. S., Bladé, J., Barlogie, B., Anderson, K., Gertz, M., Dimopoulos, M., Westin, J., Sonneveld, P., Ludwig, H., Gahrton, G., Beksac, M., Crowley, J., Belch, A., Boccadaro, M., Cavo, M., Turesson, I., Joshua, D., ... Morgan, G. (2006). International uniform response criteria for multiple myeloma. Leukemia, 20(9), 1467-1473. https://doi.org/10.1038/sj.leu.2404284

Durie, BGM, Harousseau, JL, Miguel, JS, Bladé, J, Barlogie, B, Anderson, K, Gertz, M, Dimopoulos, M, Westin, J, Sonneveld, P, Ludwig, H, Gahrton, G, Beksac, M, Crowley, J, Belch, A, Boccadaro, M, Cavo, M, Turesson, I, Joshua, D, Vesole, D, Kyle, R, Tricot, G, Alexanian, R, Attal, M, Merlini, G, Powles, R, Richardson, P, Shimizu, K, Tosi, P, Rajkumar, SV & Morgan, G 2006, 'International uniform response criteria for multiple myeloma', Leukemia, vol. 20, no. 9, pp. 1467-1473. https://doi.org/10.1038/sj.leu.2404284

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AU - Anderson, K.

AU - Gertz, M.

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AU - Turesson, I.

AU - Joshua, D.

AU - Vesole, D.

AU - Kyle, R.

AU - Tricot, G.

AU - Alexanian, R.

AU - Attal, M.

AU - Merlini, G.

AU - Powles, R.

AU - Richardson, P.

AU - Shimizu, K.

AU - Tosi, P.

AU - Rajkumar, S. V.

AU - Morgan, G.

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International uniform response criteria for multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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